{"id":82852,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-los-metodos-de-seleccion-positiva-y-expansion-ex-vivo-de-progenitores-hemopoyeticos-de-sangre-de-cordon-umbilical\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"estudio-comparativo-de-los-metodos-de-seleccion-positiva-y-expansion-ex-vivo-de-progenitores-hemopoyeticos-de-sangre-de-cordon-umbilical","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparativo-de-los-metodos-de-seleccion-positiva-y-expansion-ex-vivo-de-progenitores-hemopoyeticos-de-sangre-de-cordon-umbilical\/","title":{"rendered":"Estudio comparativo de los metodos de seleccion positiva y expansion ex vivo de progenitores hemopoyeticos de sangre de cordon umbilical."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Rodriguez Calvillo <\/strong><\/h2>\n<p>El transplante alog\u00e9nico de progenitores hemopoy\u00e9ticos se encuentra limitado por la escasez de donantes hla-compatibles y por la frecuente aparici\u00f3n de enfermedad injerto contra hu\u00e9sped. El estudio de las c\u00e9lulas de la sangre de cord\u00f3n umbilical (scu) y de su capacidad de expansi\u00f3n in vitro podr\u00eda ampliar la posibilidad de realizar trasplantes a un mayor n\u00famero de individuos.  para el estudio empleamos 21 muestras de scu y con el fin de recrear las condiciones id\u00f3neas de los ensayos de expansi\u00f3n, estudiamos la capacidad de purificaci\u00f3n de c\u00e9lulas cd34+ de dos sistemas comercializados, uno basado en un m\u00e9todo inmunomagn\u00e9tico y el otro en la inmunoadsorci\u00f3n. Adem\u00e1s, comparamos la expansi\u00f3n inducida en las dos poblaciones de c\u00e9lulas cd34+ obtenidas por estos sistemas y la comparamos con la producida en la poblaci\u00f3n mononuclear al incubarlas con suero de ternera fetal y factores de crecimiento (scf, il-3 y\/o g-csf) a lo largo de 7, 14 y 21 d\u00edas de cultivo, transcurridos los cuales se estudi\u00f3 la celularidad total y la capacidad clonog\u00e9nica de las muestras.  la recuperaci\u00f3n y pureza media de la fracci\u00f3n cd34+ fue significativamente superior en las muestras procesadas mediante el m\u00e9todo inmunomagn\u00e9tico que en las que se emple\u00f3 el sistema de inmunoadsorci\u00f3n. En cuanto a los ensayos de expansi\u00f3n, fue posible obtener adecuados crecimientos celulares en todos los ensayos iniciados. Sin embargo, el crecimiento de las c\u00e9lulas cd34+ obtenidas mediante el m\u00e9todo inmunomagn\u00e9tico se mostr\u00f3 superior, con todas las combinaciones y en todos los periodos analizados,al observado en la poblaci\u00f3n cd34+ obtenida mediante el m\u00e9todo de inmunoadsorci\u00f3n y al observado en la poblaci\u00f3n mononuclear.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de los metodos de seleccion positiva y expansion ex vivo de progenitores hemopoyeticos de sangre de cordon umbilical.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de los metodos de seleccion positiva y expansion ex vivo de progenitores hemopoyeticos de sangre de cordon umbilical. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Rodriguez Calvillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Rif\u00f3n Roca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Pardo mind\u00e1n <\/li>\n<li>Jos\u00e9 Mar\u00eda Moraleda jim\u00e9nez (vocal)<\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<li>Mar\u00eda  consuelo Juan a Del ca\u00f1izo fernandez roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Rodriguez Calvillo El transplante alog\u00e9nico de progenitores hemopoy\u00e9ticos se encuentra limitado por la escasez de donantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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