{"id":82853,"date":"2000-01-01T00:00:00","date_gmt":"2000-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-vectores-adenovirales-que-expresan-el-gen-suicida-hsv-tk-y-la-molecula-inmunopotenciadora-il-12-para-la-terapia-genica-del-cancer\/"},"modified":"2000-01-01T00:00:00","modified_gmt":"2000-01-01T00:00:00","slug":"desarrollo-de-vectores-adenovirales-que-expresan-el-gen-suicida-hsv-tk-y-la-molecula-inmunopotenciadora-il-12-para-la-terapia-genica-del-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/desarrollo-de-vectores-adenovirales-que-expresan-el-gen-suicida-hsv-tk-y-la-molecula-inmunopotenciadora-il-12-para-la-terapia-genica-del-cancer\/","title":{"rendered":"Desarrollo de vectores adenovirales que expresan el gen suicida hsv-tk y la molecula inmunopotenciadora il-12 para la terapia genica del cancer."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cheng Qian <\/strong><\/h2>\n<p>En este trabajo, hemos investigado diferentes estrategias de terapia g\u00e9nica para el tratamiento del carcinoma hepatocelular (hcc). Primeramente, hemos utilizado el vector adenoviral para vehiculizar el gende la timidin kinasa del viru herpes simplex (hsv-tk) (adcmvtk). Hemos el ganciclovir (gcv). La inyecci\u00f3n intratumoral de adcmvtk en tumores establecidos en modelos murinos de hcc conllev\u00f3 a la regresi\u00f3n de los tumores. Por otro lado, se utiliz\u00f3 la administraci\u00f3n de adcmvtk intraportal seguida de administraci\u00f3n de gcv para el tratamiento de ratas a las que se hab\u00eda inducido hcc con el carcin\u00f3geno dietil nitrosamina. En estos experimentos se observ\u00f3 una regresi\u00f3n total de los tumores en el 63% de los animales tratados. Sin embargo, este tratamiento indujo tmbi\u00e9n una muerte del 47% de los animales por la toxicidad hep\u00e1tica del tratamiento. Para reducir la toxicidad, hemos explorado nuevas estrategias con una expresi\u00f3n m\u00e1s restricitiva del gen hsv-tk en las c\u00e9lulas hcc usando el promotor de la alfa-feto proteina (afp) (adafptk). Nuestros resultados mostraron que la administraci\u00f3n de adafptk pod\u00eda  destruir selectivamente las c\u00e9ilas hcc que producen afp.Como una segunda parte del estudio, hemos usado el vector adenoviral para transferir el gen de la interleukina-12 (il-12) para potenciar la respuesta inmune antitumoral.  nuestros resultados mostraron que las c\u00e9lulas hcc pod\u00eda producir altos niveles de il-12 murina y humana tras la infecci\u00f3n con adcmvmil-12 y adcmvhil-12 respectivamente. El tratamiento por inyecci\u00f3n intratumoral de adcmvmil-12 en tumores establecidos en el modelo murino indujo un efecto supresor del crecimiento tumoral y prolong\u00f3 la supervivencia de los ratones. La hil-12 producida por las c\u00e9lulas hcc infectadas por adcmvhil-12 era funcional. Nuestros datos indican que los adenovirus recombinantes que expresan hsv-tk o bien il-12 pueden constituir armas prometedoras para el tratamiento de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de vectores adenovirales que expresan el gen suicida hsv-tk y la molecula inmunopotenciadora il-12 para la terapia genica del cancer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de vectores adenovirales que expresan el gen suicida hsv-tk y la molecula inmunopotenciadora il-12 para la terapia genica del cancer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cheng Qian <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Jimeno carruez <\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<li>pilar Civeira murillo (vocal)<\/li>\n<li>Mar\u00eda Gomez-moix anna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cheng Qian En este trabajo, hemos investigado diferentes estrategias de terapia g\u00e9nica para el tratamiento del carcinoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,962,4578,17749],"tags":[9761,150808,15059,17856,175910,17764],"class_list":["post-82853","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-genetica","category-ingenieria-genetica","category-navarra","tag-antonio-jimeno-carruez","tag-cheng-qian","tag-jesus-m-prieto-valtuena","tag-luis-montuenga-badia","tag-maria-gomez-moix-anna","tag-pilar-civeira-murillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=82853"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/82853\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=82853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=82853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=82853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}