{"id":82903,"date":"2000-12-01T00:00:00","date_gmt":"2000-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-de-los-factores-de-transcripcion-nf-kb-y-ap-1-en-la-patogenia-de-la-fibrosis-hepatica-y-en-la-hepatopatia-alcoholica\/"},"modified":"2000-12-01T00:00:00","modified_gmt":"2000-12-01T00:00:00","slug":"contribucion-de-los-factores-de-transcripcion-nf-kb-y-ap-1-en-la-patogenia-de-la-fibrosis-hepatica-y-en-la-hepatopatia-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-de-los-factores-de-transcripcion-nf-kb-y-ap-1-en-la-patogenia-de-la-fibrosis-hepatica-y-en-la-hepatopatia-alcoholica\/","title":{"rendered":"Contribucion de los factores de transcripcion nf-kb y ap-1 en la patogenia de la fibrosis hepatica y en la hepatopatia alcoholica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Roman Jimenez <\/strong><\/h2>\n<p>La mayoria de las enfermedades hepaticas cronicas se caracterizan por el desarrollo de una fibrosis incipiente que puede progresar hasta la fase final de cirrosis. Dicho proceso es tambien caracteristico de la fase final de cirrosis. Dicho proceso es tambien caracteristico de la hepatopatia alcoholica en donde se observan distintas fases desde la fibrosis hasta la cirrosis.  los mecanismos ultimos por los que el consumo cronico de etanol provoca lesiones hepaticas no estan conocidos en su totalidad debido a la naturaleza multifactorial de la patogenia. Uno de los factores que puede contribuir a la patogenia de la enfermedad alcoholica es un metbolito del etanol, el acetaldehido. Diversos estudios han puesto de manifiesto el efecto de acetaldehido sobre la activacion de la transcripcion de los genes en colageno en diversos tipos celulares, efecto que esta mediado por factores de transcripcion.  otro factor importante en la enfermedad hepatica alcoholica es la inflamaci\u00f3n. de especial importancia es la activacion de la expresi\u00f3n de citoquinas que ejercerian una atracci\u00f3n de celulas inflamatorias a lugares especificos. dichas citoquinas est\u00e1n reguladas por los factores de transcripci\u00f3n ap-1 y nf-kb.  en la actualidad no existe una terapia definitiva en el tratamiento de la enfermedad hepatica alcoholica, sin embargo, agentes hepatoprotectores como s-adenoslmetionina demuestran un efecto terapeutico prometedor.  asi, los objetivos de la presente tesis fueron:  1-determinar la actividad de los factores de transcripcion ap-1 y nf-kb en un modelo animal de induccion a la cirrosis. Papel del same.  2-investigar el papel del acetaldehido en la generaci\u00f3n de estr\u00e9s oxidativo y en la actividad de ap-1 y nf-kb.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion de los factores de transcripcion nf-kb y ap-1 en la patogenia de la fibrosis hepatica y en la hepatopatia alcoholica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion de los factores de transcripcion nf-kb y ap-1 en la patogenia de la fibrosis hepatica y en la hepatopatia alcoholica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Roman Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>checa Torres Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carles Enrich bast\u00fas <\/li>\n<li>joan Claria enrich (vocal)<\/li>\n<li>Mar\u00eda  dolores Lopez tejedor (vocal)<\/li>\n<li>Jorge Camps andreu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Roman Jimenez La mayoria de las enfermedades hepaticas cronicas se caracterizan por el desarrollo de una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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