{"id":82904,"date":"2000-12-01T00:00:00","date_gmt":"2000-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximaciones-a-la-sa%c2%adntesis-qua%c2%admica-de-protea%c2%adnas\/"},"modified":"2000-12-01T00:00:00","modified_gmt":"2000-12-01T00:00:00","slug":"aproximaciones-a-la-sa%c2%adntesis-qua%c2%admica-de-protea%c2%adnas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aproximaciones-a-la-sa%c2%adntesis-qua%c2%admica-de-protea%c2%adnas\/","title":{"rendered":"Aproximaciones a la s\u00edntesis qu\u00edmica de prote\u00ednas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Adeva Anton <\/strong><\/h2>\n<p>En la tesis se ha abordado la s\u00edntesis por m\u00e9todos qu\u00edmicos de sistemas prote\u00edcos, empleando tanto aproximaciones cl\u00e1sicas como nuevas metodolog\u00edas. en una primera parte del trabajo se ha sintetizado la prote\u00edna anticongelante tipo iii (afp iii) del macrozoarces americanus, con una longitud de 65 residuos, empleando una estrategia lineal de s\u00edntesis en fase s\u00f3lida, altenativamente seg\u00fan un esquema de protecci\u00f3n boc\/bzl o fmoc\/bu. Aunque tambi\u00e9n se ha abordado la s\u00edntesis mediante una estrategia de ligadura qu\u00edmica tio\u00e9ster esta metodolog\u00eda no ha permitido alcanzar el objetivo sint\u00e9tico deseado, si bien se ha aplicado con \u00e9xito a la obtenci\u00f3n de un modelo pept\u00eddico sencillo.  en el segundo cap\u00edtulo se ha desarrollado una nueva metodolog\u00eda de ligadura qu\u00edmica nativa, que ha sido aplicada con \u00e9xito a la obtenci\u00f3n del dominio sh3 de la prote\u00edna quinasa de abelson (abl-sh3), de 56 residuos. Esta aproximaci\u00f3n se basa en el empleo de una resina pega-nh2, modificada para la obtenci\u00f3n de p\u00e9ptidos desprotegidos anclados al soporte s\u00f3lido a trav\u00e9s de un enlace tio\u00e9ster, y ofrece una gran versatilidad en cuanto a la obtenci\u00f3n de diferentes funcionalizaciones en posici\u00f3n c-terminal de un p\u00e9ptido a partir de un substrato \u00fanico. Por otra parte, se ha desarrollado un procedimiento para la purificaci\u00f3n in situ de dominios proteicos sintetizados mediante esta modalidad de ligadura qu\u00edmica nativa, basado en la afinidad por ligandos pept\u00eddicos.  por \u00faltimo, se ha abordado la s\u00edntesis del dominio pdz-3 de la prote\u00edna psd-95, con una talla de 96 residuos. En este caso se ha segudio una estrategia de tipos ecuencial, basada en la metodolog\u00eda descrita en el segundo cap\u00edtulo, a partir de tres segmentos pept\u00eddicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aproximaciones a la s\u00edntesis qu\u00edmica de prote\u00ednas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aproximaciones a la s\u00edntesis qu\u00edmica de prote\u00ednas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Adeva Anton <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Andreu Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Pedroso muller <\/li>\n<li>Rafael Franco fernandez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Melero fondevilla (vocal)<\/li>\n<li>ramon Eritja casadell\u00ed\u00a0 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Adeva Anton En la tesis se ha abordado la s\u00edntesis por m\u00e9todos qu\u00edmicos de sistemas prote\u00edcos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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