{"id":82962,"date":"2018-03-10T00:07:03","date_gmt":"2018-03-10T00:07:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunomodulacion-y-efectos-hematopoyeticos-de-la-interleucina-2-sobre-productos-de-leucoaferesis-obtenidos-para-autrasplante-de-progenitores-de-sangre-periferica\/"},"modified":"2018-03-10T00:07:03","modified_gmt":"2018-03-10T00:07:03","slug":"inmunomodulacion-y-efectos-hematopoyeticos-de-la-interleucina-2-sobre-productos-de-leucoaferesis-obtenidos-para-autrasplante-de-progenitores-de-sangre-periferica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inmunomodulacion-y-efectos-hematopoyeticos-de-la-interleucina-2-sobre-productos-de-leucoaferesis-obtenidos-para-autrasplante-de-progenitores-de-sangre-periferica\/","title":{"rendered":"Inmunomodulacion y efectos hematopoyeticos de la interleucina 2, sobre productos de leucoaferesis obtenidos para autrasplante de progenitores de sangre periferica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cervero Santiago Carlos Javier <\/strong><\/h2>\n<p>Conclusiones.1)entre las diferentes poblaciones de celulas mononucleadas presentas en las leucoaf\u00e9resis utilizadas en el trasplante autologo de progenitores hematopoy\u00e9ticos de sangre periferica, es posible detectar la presencia de linfocitos t, y celulas nk susceptibles de actuar como celulas efectoras de la actividad antitumoral mediante su activacion con interleucina 2.2) tras su crioconservacion, des-congelacion y cultivos de altas concentraciones (1000ui\/ml) de interleucina -2 durante 48 horas, no se detecta una respuesta proliferativa de celulas nk o t, aunque es posible observar un incremento en la expresion de antigenos marcadores de activacion celular en dichas celulas. Los estudios de citotoxicidad ponen de manifiesto un aumento de la actividad litica de las celulas incubadas con interleucina-2 frente a ciertas lineas de celulas tumorales nk-sensibles como k562. La incubacion de 48 horas no es suficiente para garantizar un aumento significativo de la actividad litica frente a celulas de linea tumoral nk-resistente como raji. 3)tras la incubacion de 14 dias con concentraciones bajas de interleucina-2 es posible observar un aumento en la proporcion de linfocitos nk y en la expresion de dicha poblacion celular, de antigenos marcadores de activacion. Los estudios de citotoxicidad demuestran un incremento de la actividad litica frente a celulas de lineas tumorales nk-sensibles como k562 ynk-resistentes como raji, tras 14 dias de incubacion con concentraciones de 10 ui\/ml de interleucina-2. Este hecho corrobora que el proceso de activacion celular,iniciado con concentraciones altas de interleucina-2, puede ser mantenido con el tiempo e incluso incrementado con concentraciones bajas de dicha citocina, susceptibles de ser alcanzadas \u00abin vivo\u00bb en el paciente sometido a trasplante. 4) la citometria de flujo ha demostrado ser un metodo valido y reproducible para llevar a cabo estudios de citotoxicidad. 5) los progenitores hematopoyeticos de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunomodulacion y efectos hematopoyeticos de la interleucina 2, sobre productos de leucoaferesis obtenidos para autrasplante de progenitores de sangre periferica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunomodulacion y efectos hematopoyeticos de la interleucina 2, sobre productos de leucoaferesis obtenidos para autrasplante de progenitores de sangre periferica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cervero Santiago Carlos Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Lopez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Rafael Cabrera martin (vocal)<\/li>\n<li>Jos\u00e9 Francisco Tomas Martinez (vocal)<\/li>\n<li>Francisco Mampaso martin buitrago (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cervero Santiago Carlos Javier Conclusiones.1)entre las diferentes poblaciones de celulas mononucleadas presentas en las leucoaf\u00e9resis utilizadas en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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