{"id":83054,"date":"2018-03-10T00:07:07","date_gmt":"2018-03-10T00:07:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-lipoprotea%c2%adna-a-enla-hipercolesterolemia-familiar-y-su-relacion-con-las-alteraciones-del-receptor-del-ldl-y-la-cardiopata%c2%ada-isquemica\/"},"modified":"2018-03-10T00:07:07","modified_gmt":"2018-03-10T00:07:07","slug":"estudio-de-la-lipoprotea%c2%adna-a-enla-hipercolesterolemia-familiar-y-su-relacion-con-las-alteraciones-del-receptor-del-ldl-y-la-cardiopata%c2%ada-isquemica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-lipoprotea%c2%adna-a-enla-hipercolesterolemia-familiar-y-su-relacion-con-las-alteraciones-del-receptor-del-ldl-y-la-cardiopata%c2%ada-isquemica\/","title":{"rendered":"Estudio de la lipoprote\u00edna (a) enla hipercolesterolemia familiar y su relaci\u00f3n con las alteraciones del receptor del ldl, y la cardiopat\u00edaisqu\u00e9mica."},"content":{"rendered":"

Tesis doctoral de Susana Ten\u00e9s Rodrigo <\/strong><\/h2>\n

Introduccion la lp(a) es una lipoprote\u00edna ldl modificada cuyos niveles elevados confieren un mayor riesgo cardiovascular. Se ha postulado que la lp(a) podr\u00eda ser aclarada del plasma por la via del receptor ldl (r-ldl), aunque los datos al respecto son contradictorios. La hipercolesterolemia familiar (hf) es una enfermedad debida a mutadciones en el gen del receptor de ldl que cursa con niveles elevados de ldl-c y, seg\u00fandiferentes estudios, niveles elevados de lp(a) de causa no conocida. En la hf existe gran variabilidad en la preValencia y gravedad de eventos cardiovasculares no explicable exclusivamente por los niveles de ldl-c circulante. La hiperlipemia familiar combinada (hfc) representa un modelo gen\u00e9tico opuesto a la hf ya existe un aumento de la s\u00edntesis hep\u00e1tica de apo b con funcionamiento del r-ldl normal. hipotesis y objetivos \u00abla lp(a) plasm\u00e1tica se encuentra elevada enla hf debido al funcionamiento defectuso del r-ldl y este aumetno se relaciona con la elevada preValencia de cardiopta\u00eda isqu\u00e9mica (ci) en estos pacientes\u00bb. Nuestros objetivos son: 1- conocer si los niveles de lp(a) est\u00e1n elevados en sujetos hf libres de enfermedad cardiovascular. 2- estudiar los niveles de lp(a) en la hfc, como modelo gen\u00e9tico opuesto a la hf, para analizar el valor de la hiperproducci\u00f3n hep\u00e1tica de apo b sobre los niveles de lp(a). 3- comprobar si los niveles de lp(a) est\u00e1n ligados a la transmisi\u00f3n del alelo mutante. 4- conocer la influencia de las mutaciones del gen del r-ldl sobre los niveles de lp(a). 5- estudiar la asocaci\u00f3n de la lp(a) con la cardiopat\u00eda isqu\u00e9mica en la hf. material y metodos cuatro grupos de sujetos: 1- hf: compuesto por 90 probandos hf diagn\u00f3sticados con criterios cl\u00ednicos y gen\u00e9ticos (30 con ci y 60 sin ci). 2- hfc: compuesto por 36 probandos hfc sinci, diagn\u00f3sticados por criterios cl\u00ednicos. 3- familiares de primer grado sanos de sujetos hf: 41 sujetos sin dislipemia<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEstudio de la lipoprote\u00edna (a) enla hipercolesterolemia familiar y su relaci\u00f3n con las alteraciones del receptor del ldl, y la cardiopat\u00edaisqu\u00e9mica.<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la lipoprote\u00edna (a) enla hipercolesterolemia familiar y su relaci\u00f3n con las alteraciones del receptor del ldl, y la cardiopat\u00edaisqu\u00e9mica. <\/li>\n
  • Autor:<\/strong>\u00a0 Susana Ten\u00e9s Rodrigo <\/li>\n
  • Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 21\/01\/2000<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Rafael Carmena Rodriguez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: vicente Lopez merino <\/li>\n
        • guillermo Saez tormo (vocal)<\/li>\n
        • celestino Rey-joly barroso (vocal)<\/li>\n
        • Fernando Espi Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Susana Ten\u00e9s Rodrigo Introduccion la lp(a) es una lipoprote\u00edna ldl modificada cuyos niveles elevados confieren un mayor […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,851,139],"tags":[1492,8440,12108,11685,176210,11497],"class_list":["post-83054","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endocrinologia","category-medicina-interna","tag-celestino-rey-joly-barroso","tag-fernando-espi-Martinez","tag-guillermo-saez-tormo","tag-rafael-carmena-rodriguez","tag-susana-tenes-rodrigo","tag-vicente-lopez-merino"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83054"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83054\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}