{"id":83076,"date":"2018-03-10T00:07:10","date_gmt":"2018-03-10T00:07:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-de-p53-en-relacion-con-la-queratosis-actinica\/"},"modified":"2018-03-10T00:07:10","modified_gmt":"2018-03-10T00:07:10","slug":"contribucion-al-estudio-de-p53-en-relacion-con-la-queratosis-actinica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-estudio-de-p53-en-relacion-con-la-queratosis-actinica\/","title":{"rendered":"Contribuci\u00f3n al estudio de p53 en relaci\u00f3n con la queratosis act\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvestre Martinez Garcia <\/strong><\/h2>\n<p>Introduccion: en la presente tesis se realiza un estudio descriptivo el p53 y su expresi\u00f3n en la dermatolog\u00eda como es la queratosis act\u00ednica.  situacion actual: est\u00e1 dividida en dos grandes apartados, uno dedicado a la queratosis act\u00ednica, y otro a p53.  en el primero, se explica todos los aspectos de esta patolog\u00eda, destacando el tema de los factores etiopatog\u00e9nicos, donde se dedica gran parte del apartado a desarrollar el estudio de las radiaciones ultravioletas, al ser el principal factor productor que la queratosis act\u00ednica.  en el segundo, se estudia la prote\u00edna p53, sintetizada por un gen con el mismo nombre, que act\u00faa como freno de emergencia deteniendo la multiplicaci\u00f3n de c\u00e9lulas defectuosas. Pero cuando radiaciones o sustancias da\u00f1inas modifican este gen, pierde su capacidad de frenar la proliferaci\u00f3n celular, constituyendo el inicio de carcinomas.  material y metodo:40 casos de queratosis act\u00ednica. Las biopsias, realizadas a nivel facial,se han dividido en tres zonas, el centro de la lesi\u00f3n el borde y la zona de piel sana que rodea la queratosis. Valor\u00e1ndose, con inmunohistoqu\u00edmica, la expresi\u00f3n y forma de distribuci\u00f3n de la prote\u00edna p53 en dichas zonas y en las diferentes capas de la epidermis.  resultados: se analizan varios factores(sexo,edad,fenotipo,grado de insolaci\u00f3n, envejecimiento cl\u00ednico, tipo histopatol\u00f3gico y grado de displasia), en un primero momento de manera individual, para posteriormente, mediante prueba estad\u00edsticas, relacionarlos con la expresi\u00f3n de p53.  conclusiones: destacan:  -la expresi\u00f3n de p53 desminuye a medida que se aleje de la zona de lesi\u00f3n de la biopsia, y se aproxime a capa c\u00f3rnea.  -la forma de distribuci\u00f3n pasa de focal a difusa desde el centro a la periferia de la lesi\u00f3n.  -el envejecimiento cut\u00e1neo, es el factor donde los resultados han dado un valor m\u00e1s estadisticamente significativo (p&lt;0,05) en relaci\u00f3n con la expresi\u00f3n de p53.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuci\u00f3n al estudio de p53 en relaci\u00f3n con la queratosis act\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n al estudio de p53 en relaci\u00f3n con la queratosis act\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvestre Martinez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Calap Calatayud<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Oca\u00f1a sierra <\/li>\n<li> Wilhelmi de cal M\u00aa Luisa (vocal)<\/li>\n<li>Manuel Rosety plaza (vocal)<\/li>\n<li>Manuel Gutierrez rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvestre Martinez Garcia Introduccion: en la presente tesis se realiza un estudio descriptivo el p53 y su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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