{"id":83083,"date":"2018-03-10T00:07:10","date_gmt":"2018-03-10T00:07:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mucosa-oral-obtenida-in-vitro-diseno-caracterizacion-y-aplicacion-experimental-de-tres-modelos\/"},"modified":"2018-03-10T00:07:10","modified_gmt":"2018-03-10T00:07:10","slug":"mucosa-oral-obtenida-in-vitro-diseno-caracterizacion-y-aplicacion-experimental-de-tres-modelos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mucosa-oral-obtenida-in-vitro-diseno-caracterizacion-y-aplicacion-experimental-de-tres-modelos\/","title":{"rendered":"\u00abmucosa oral obtenida in vitro: dise\u00f1o, caracterizaci\u00f3n y aplicaci\u00f3n experimental de tres modelos\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Mendez M. Soledad <\/strong><\/h2>\n<p>Para el tratamiento de diversas patolog\u00edas del territorio oral(carcinomas, leucoplasias extensas, grandes liquenes erosivos, defectos peridontales y perimplantarios, etc.)Se requiere la obtenci\u00f3n de injertos aut\u00f3logos de origen cut\u00e1neo(o mucoso) que am\u00e9n de incrementar la morbalidad en el paciente, no suelen ajustarse a las exigencias funcionales y est\u00e9ticas que el teritorio receptor demanda. En el presente estudio se procedi\u00f3 a la obtenci\u00f3n de un equivalente de mucosa oral completa, mediante t\u00e9cnicas de cultivo in vitro. A partir de peque\u00f1as biopsias de mucosa oral se hicieron cultivos primarios de queratinocitos seg\u00fan el m\u00e9todo descrito por rheinwald y green. A partir de este cultivo primari se realizaron cultivos secundarios en tres tipos diferentes de submucosa artificial(col\u00e1geno con fibroblastos humanos). Se demostr\u00f3 su viabilidad cl\u00ednica mediante su aplicaci\u00f3n como injerto en ratones atimicos. El estudio morfol\u00f3gico realizado mediante tinci\u00f3n convencional y estudio inmunohistoqu\u00edmico(citoqueratinas, receptores ngf,receptores egf, y prote\u00ednas de membrana basal), revel\u00f3 la validez de las diferentes mucosas artificiales como injerto. La submucosa de fibrina es, seg\u00fan la experiencia del presente trabajo, la m\u00e1s apropiada teniendo en cuanta la posible utilizaci\u00f3n de prote\u00edna aut\u00f3loga.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abmucosa oral obtenida in vitro: dise\u00f1o, caracterizaci\u00f3n y aplicaci\u00f3n experimental de tres modelos\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abmucosa oral obtenida in vitro: dise\u00f1o, caracterizaci\u00f3n y aplicaci\u00f3n experimental de tres modelos\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Mendez M. Soledad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Sebastian Lopez Arranz Arranz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Paz jimenez <\/li>\n<li>narciso P\u00e9rez  oliva (vocal)<\/li>\n<li>Antonio Bascones Martinez (vocal)<\/li>\n<li>Alberto Berguer sandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Mendez M. Soledad Para el tratamiento de diversas patolog\u00edas del territorio oral(carcinomas, leucoplasias extensas, grandes liquenes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,332,141,140,46207,8846,925],"tags":[7476,7111,176254,27899,37900,9203],"class_list":["post-83083","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-ciencias-tecnologicas","category-cirugia","category-estomatologia-y-ortodoncia","category-organos-artificiales","category-oviedo","category-tecnologia-medica","tag-alberto-berguer-sandez","tag-antonio-bascones-Martinez","tag-gonzalez-mendez-m-soledad","tag-jose-paz-jimenez","tag-juan-sebastian-lopez-arranz-arranz","tag-narciso-perez-oliva"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83083"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83083\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}