{"id":83106,"date":"2018-03-10T00:07:10","date_gmt":"2018-03-10T00:07:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-liberacion-de-clutamato-por-receptores-metabotropicos-del-grupo-i-y-por-la-va%c2%ada-no-gmpc\/"},"modified":"2018-03-10T00:07:10","modified_gmt":"2018-03-10T00:07:10","slug":"modulacion-de-la-liberacion-de-clutamato-por-receptores-metabotropicos-del-grupo-i-y-por-la-va%c2%ada-no-gmpc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modulacion-de-la-liberacion-de-clutamato-por-receptores-metabotropicos-del-grupo-i-y-por-la-va%c2%ada-no-gmpc\/","title":{"rendered":"Modulaci\u00f3n de la liberaci\u00f3n de clutamato por receptores metabotr\u00f3picos del grupo i y por la v\u00edano\/gmpc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alessandra Sistiaga Hernando <\/strong><\/h2>\n<p>La tesis doctoral presentada por la doctoranda d\u00aa alessandra sistiaga hernando estudia el papel modulador, tanto de la v\u00eda no\/gmpc, como de la activaci\u00f3n de los receptores metabotr\u00f3picos del grupo i, sobre la liberaci\u00f3n de glutamato. En ella se pone de manifesto que los receptores metabotr\u00f3picos del grupo i son capaces tanto de potenciar como inhibir la transmisi\u00f3n sin\u00e1ptica y la liberaci\u00f3n de glutamato, en funci\u00f3n de la concentraci\u00f3n de glutamato extracelular. As\u00ed, cuando la concentraci\u00f3n de glutamato extracelular es baja (aproximadamente 1um), el receptor facilita la liberaci\u00f3n de glutamato y la transmisi\u00f3n sin\u00e1ptica por un mecanismo dependiente de la activaci\u00f3n de la prote\u00edna quinasa c por el diacilglicerol generado tras la estimulaci\u00f3n del receptor. Sin embargo, la activaci\u00f3n repetida del receptor, que puede tener lugar por un ligero incremento en la concentraci\u00f3n de glutamato extracelular, desnsibiliza la respuesta facilitadora, manifest\u00e1ndose un efecto inhibidor tanto de la transmisi\u00f3n sin\u00ed\u00a0ptica como de la liberaci\u00f3n de glutamato. Esta inhibici\u00f3n se produce como consecuencia de una disminuci\u00f3n en la actividad de los canales de ca2+ del tipo n, y se produce por acoplamiento del receptor a una prote\u00edna g insensible a toxina pert\u00fasica y el canal de ca2+. El acoplamiento del receptor a la v\u00eda inhibidora podr\u00eda ser debido a la fosforilaci\u00f3n del receptor por la prote\u00edna quinasa c. Una prote\u00edna fosfatada del tipo 1\/2 a est\u00e1 implicada en la defosforilaci\u00f3n del receptor, y por tanto en la recuperaci\u00f3n de la respuesta facilitadora. Los efectos inducidos tras la activaci\u00f3n de este receptor sobre la transmisi\u00f3n sin\u00e1ptica, son debidos a una modificai\u00f3n en la liberaci\u00f3n de neurotransmisor, lo que indica una localizaci\u00f3n presin\u00e1ptica del efecto. La identidad del receptor que induce estos efectos no se conoce, aunque los experimentos realizados en ratones que carecen de mglur1 indican que no es este receptor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la liberaci\u00f3n de clutamato por receptores metabotr\u00f3picos del grupo i y por la v\u00edano\/gmpc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la liberaci\u00f3n de clutamato por receptores metabotr\u00f3picos del grupo i y por la v\u00edano\/gmpc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alessandra Sistiaga Hernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>prieto Borja S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ruiz amil <\/li>\n<li>Juan Lerma g\u00f3mez (vocal)<\/li>\n<li>federico Lerma men\u00e9ndez (vocal)<\/li>\n<li>Rafael Lujan miras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alessandra Sistiaga Hernando La tesis doctoral presentada por la doctoranda d\u00aa alessandra sistiaga hernando estudia el papel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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