{"id":8312,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-la-interaccion-farmacocinetica-de-la-teofilina-con-un-nuevo-antihistaminico-h1-en-voluntarios-sanos\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-la-interaccion-farmacocinetica-de-la-teofilina-con-un-nuevo-antihistaminico-h1-en-voluntarios-sanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-interaccion-farmacocinetica-de-la-teofilina-con-un-nuevo-antihistaminico-h1-en-voluntarios-sanos\/","title":{"rendered":"Estudio de la interaccion farmacocinetica de la teofilina con un nuevo antihistaminico h1 en voluntarios sanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Vicente Juan  Antonio <\/strong><\/h2>\n<p>La administracion concomitante de teofilina y antihistaminicos h1 es una practica terapeutica posible, por lo que resulta interesante conocer si ambos tratamientos presentan interacciones. Mizolastina: es un nuevo antihistaminico h1 que actua preferentemente a nivel periferico (menor incidencia de efectos sedantes) y con escasos efectos anticolinergicos. Su principal indicacion es la ritinitis alergica estacional a dosis de 10 mg al dia (en una toma), siendo efectivo y bien tolerado.  objetivo: estudiar la eventual interaccion farmacocinetica en estado de equilibrio de la mizolastina (10 mg\/dia durante 2 semanas) con la teofilina (300 mg\/12 horas durante 5 dias) en voluntarios sanos.  metodolog\u00eda: se trata de un ensayo clinico cruzado, aleatorizado, doble ciego, controlado con placebo, con dos periodos de tratamiento de 15 dias cada uno, separados por un periodo de blanqueo de 14 dias.  participaron 16 voluntarios sanos varones, no fumadores de edades comprendidas entre los 18 y los 40 a\u00f1os. Los voluntarios tomaron la medicacion en presencia del investigador, tras la realizacion de las extracciones sanguineas para obtener los niveles plasmaticos de mizolastina, teofilina y sus metabolitos (acido 1,3-dimetilurico y 3-metilxantina).  resultados: los parametros farmacocineticos de la teofilina y sus metabolitos no se alteraron con la coadministracion de mizolastina, excepto la biodisponibilidad de la teofilina. Los valores de auco-12 (area bajo la curva de 0 a 12 horas) fueron mayores tras la administracion conjunta. Tambien aumento la produccion del acido 1,3-dimetilurico en presencia de mizolastina.  la cmin (concentracion plasmatica minima en estado de equilibrio) de teofilina fue superior cuando se administraron conjuntamente, a las 96, 108 y 120 horas de la primera administracion.  conclusiones: la mizolastina no afecta de forma significativa el metabolismo y la farmacocinetica de la teofilina, salvo en un aumento liger<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interaccion farmacocinetica de la teofilina con un nuevo antihistaminico h1 en voluntarios sanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interaccion farmacocinetica de la teofilina con un nuevo antihistaminico h1 en voluntarios sanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Vicente Juan  Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pau Salva Lacombe<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Salva Miquel <\/li>\n<li>Javier Forn Dalmau (vocal)<\/li>\n<li>Francesc Jan\u00e9 Carrenca (vocal)<\/li>\n<li>Manuel Monreal Bosch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Vicente Juan Antonio La administracion concomitante de teofilina y antihistaminicos h1 es una practica terapeutica posible, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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