{"id":83176,"date":"2018-03-10T00:07:14","date_gmt":"2018-03-10T00:07:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/programa-de-seguimiento-de-clozapina\/"},"modified":"2018-03-10T00:07:14","modified_gmt":"2018-03-10T00:07:14","slug":"programa-de-seguimiento-de-clozapina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/programa-de-seguimiento-de-clozapina\/","title":{"rendered":"Programa de seguimiento de clozapina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Blanca Santamaria Ruiz <\/strong><\/h2>\n<p>Intruducci\u00f3n: en septiembre de 1993 se re-comercializ\u00f3 en espa\u00f1a clozapina, un antipsic\u00f3tico at\u00edpico que ha demostrado ser m\u00e1s eficaz que los antipsic\u00f3ticos cl\u00e1sicos en pacientes que no responden al tratamiento o no toleran los efectos adversos extrapiramidales de los antipsic\u00f3ticos cl\u00e1sicos, a la par que carece pr\u00e1cticamente de dichos efectos. Su introducci\u00f3n en el mercado se realiz\u00f3 bajo condiciones especiales que afectaban a su indicaci\u00f3n(esquizofrenia resistente), prescripci\u00f3n(limitada a psiquiatras) y utilizaci\u00f3n(recuentos leucocitarios pero\u00f3dicos) debido al elevado riesgo de producir agranulocitosis(1%-3%). para controlar el cumplimiento de las condiciones de uso atorizadas y facilitar su utilizaci\u00f3n se puso en marcha un programa de seguimientos. Planteamiento y objetivos: evaluar los resultados de los 3 primeros a\u00f1os del programa de seguimiento de clozapina en espa\u00f1a desde las siguientes perspectivas: c\u00f3mo se utiliz\u00f3 clozapina, cu\u00e1l era su perfil de seguridad y si el programa consigui\u00f3 facilitar y controlar el cumplimiento de la correcta utilizaci\u00f3n de clozapina. Este trabajo se complet\u00f3 con un an\u00e1lisis del consumo de clozapina en espa\u00f1a en relaci\u00f3n con el consumo de los dem\u00e1s antipsic\u00f3ticos, desde enero de 1993 a diciembre a 1998. Pacientes y m\u00e9todos: la informaci\u00f3n se ha extra\u00eddo de la base de datos de clozapina que incluye informaci\u00f3n de variables sociodemogr\u00e1ficas, cl\u00ednicas y del tratamiento. En la cohorte de pacientes se realiz\u00f3 un an\u00e1lisis de supervivencia para estimar la incidencia de leucopenia, neutropenia, agranulocitosis, as\u00ed como de otras variables. tambi\u00e9n se realiz\u00f3 un an\u00e1lisis de casos y controles anidado en la cohorte para tratar de identificar factores de riesgo asociados a estos trastornos leucocitarios. La informaci\u00f3n sobre el consumo de antipsic\u00f3ticos procede de la base de datos ecom,far90 y de los datos de ventas proporcionados por el titular de la autorizaci\u00f3n de come<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Programa de seguimiento de clozapina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Programa de seguimiento de clozapina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Blanca Santamaria Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dolores Montero Coromina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De Andr\u00e9s rodriguez p\u00e9rez fernando <\/li>\n<li>Jos\u00e9 Jim\u00e9nez mart\u00edn (vocal)<\/li>\n<li>enrique Alvarez Martinez (vocal)<\/li>\n<li>ram\u00f3n Palop baixauli (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Blanca Santamaria Ruiz Intruducci\u00f3n: en septiembre de 1993 se re-comercializ\u00f3 en espa\u00f1a clozapina, un antipsic\u00f3tico at\u00edpico que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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