{"id":83178,"date":"2018-03-10T00:07:14","date_gmt":"2018-03-10T00:07:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/uso-del-receptor-de-antigeno-de-la-celula-t-tcr-en-procesos-patologicos-estudios-en-la-enfermedad-de-injerto-contra-huesped-aguda-aeich-y-en-espondiloartropatias\/"},"modified":"2018-03-10T00:07:14","modified_gmt":"2018-03-10T00:07:14","slug":"uso-del-receptor-de-antigeno-de-la-celula-t-tcr-en-procesos-patologicos-estudios-en-la-enfermedad-de-injerto-contra-huesped-aguda-aeich-y-en-espondiloartropatias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/uso-del-receptor-de-antigeno-de-la-celula-t-tcr-en-procesos-patologicos-estudios-en-la-enfermedad-de-injerto-contra-huesped-aguda-aeich-y-en-espondiloartropatias\/","title":{"rendered":"Uso del receptor de antigeno de la celula t (tcr) en procesos patologicos. estudios en la enfermedad de injerto contra huesped aguda (aeich) y en espondiloartropatias"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Trevi\u00f1o Avellaneda Miguel Angel <\/strong><\/h2>\n<p>Las c\u00e9lulas t respnden a ant\u00edgenos tras reconocerlos a trav\u00e9s de sus receptores de ant\u00edgeno de la c\u00e9lula t (tcrs), complejos altamente polim\u00f3rficos y clonalmente distribuidos con una elevada especificidad antig\u00e9nica.  la existencia de enfermedades en las que se ha descrito la existencia de da\u00f1os tisulares infiltrados pro c\u00e9lulas t indica la posible  implicaci\u00f3n de \u00e9stas en el proceso patog\u00e9nico que conduce al desarrollo de la afecci\u00f3n, probablemente mediante el reconocimiento y respuesta contra ant\u00edgenos localizados en los tejidos afectados.  la presente investigaci\u00f3n se centra en el estudio de los tcrs en diferentes patolog\u00edas: en efermedad de injerto contra hu\u00e9sped aguda (aeich) y en esponfiloartropat\u00edas.  el estudio de las c\u00e9lulas t en infiltrados de piel de enfermos afectados por aeich ha revelado que todas las c\u00e9lulas t aisladas responden a alelos hla expresados por el receptor pero no por el donante, que sus tcrs son extremadamente heterog\u00e9neos y que su espcialidad de tejido parece relacionada con el reconocimiento de ant\u00edgenos espec\u00edficos de tejido.  el estudio de las espondiloartropat\u00edas revela la existencia de expansiones oligoclonales entre los tcrs expresados por las c\u00e9lulas t de las muestras locales que indican la implicaci\u00f3n de c\u00e9lulas t espec\u00edficas de ant\u00edgenos convencionales en el desarrollo y mantenimiento de estas enfermedades. las c\u00e9lulas que expresan uno de los tcrs espec\u00edficamente aumentados en las lesiones fueron capaces de responder contra c\u00e9lulas propias, lo cual apunta a que las enfermedades de este grupo pueden ser de origen autoinmune.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Uso del receptor de antigeno de la celula t (tcr) en procesos patologicos. estudios en la enfermedad de injerto contra huesped aguda (aeich) y en espondiloartropatias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Uso del receptor de antigeno de la celula t (tcr) en procesos patologicos. estudios en la enfermedad de injerto contra huesped aguda (aeich) y en espondiloartropatias <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Trevi\u00f1o Avellaneda Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Bragado Herrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>Antonio Ba\u00f1ares ca\u00f1izares (vocal)<\/li>\n<li>Fernando Ortiz masllorens (vocal)<\/li>\n<li> Barbolla garcia m. luz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Trevi\u00f1o Avellaneda Miguel Angel Las c\u00e9lulas t respnden a ant\u00edgenos tras reconocerlos a trav\u00e9s de sus receptores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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