{"id":83282,"date":"2000-08-02T00:00:00","date_gmt":"2000-08-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelado-farmacocinetico-y-farmacodinamico-de-ciclofosfamida-en-pacientes-con-cancer-de-mama\/"},"modified":"2000-08-02T00:00:00","modified_gmt":"2000-08-02T00:00:00","slug":"modelado-farmacocinetico-y-farmacodinamico-de-ciclofosfamida-en-pacientes-con-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelado-farmacocinetico-y-farmacodinamico-de-ciclofosfamida-en-pacientes-con-cancer-de-mama\/","title":{"rendered":"\u00abmodelado farmacocin\u00e9tico y farmacodinamico de ciclofosfamida en pacientes con cancer de mama\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jose Perez Ruixo <\/strong><\/h2>\n<p>La estrategia terap\u00e9utica multidiciplinar del cancer de mama ha permitido conseguir un excelente control local de la enfermedad en el 80-90% de los casos, y cerca del 30% de los pacientes permanecen libres de enfermedad tras 10 a\u00f1os. En pacientes de alto riesgo, una de las estrategias terap\u00e9uticas m\u00e1s prometedoras es la administraci\u00f3n de altas dosis de quimioterapia y soporte hematol\u00f3gico. La utilizaci\u00f3n de altas dosis de citostaticos se objetiva por la excelente relaci\u00f3n dosis-respuesta existente, tal y como sucede con la ciclofosfamida.  el inter\u00e9s por conocer y cuantificar las distintas fuentes de variabilidad en la respuesta farmacol\u00f3gica a ciclofosfamida, se fundamenta en la hipotesis de que, reducir variabilidad en la exposici\u00f3n del organismo al farmaco, es disminuir variabilidad en su respuesta cl\u00ednica. Este objetivo, se alcanza de forma m\u00e1s directa, cuando se estudia la relaci\u00f3n existente entre la concentracion de farmaco en el organismo y su respuesta clinica que, cuando se hace con respecto a la dosis-respuesta. El objetivo principal de la memoria es caracterizar el comportamiento farmacocin\u00e9tico y farmacodin\u00e1mico de ciclofosfamida administrada a dosis altas en pacientes adultos con c\u00e1ncer de mama de alto riesgo. Las conclusiones obtenidas m\u00e1s relevantes son:  1.- Los par\u00e1metros farmacocineticos poblacionales de ciclofosfamida, estimados mediante el modelo no lineal de efectos mixtos,son el volumen de distribucion 24.10 l(ic95%:14.71 a33.29), aclaramiento plasm\u00e1tico inicial 2.17 l\/h (ic95%: 1.88 a 2.45 l\/h) y constante de inducci\u00f3n 0.0124 l\/h2(ic95%:0.0071 a 0.0177 l\/h2). La variabilidad interindividual asociada a cada uno de estos parametros es 68.12%(ic95% :47.33 a 83.90%),29,56%(ic95%:25.06 a 33.45%) y 75.56%(ic95%:53.65 a 92.41%), respectivamente. La estimacion de la variabilidad residual es 15.65%(ic95%:9.40 a 20.04%).  2.-Los factores de riesgo asociados con la aparaci\u00f3n de proteccion completa o may<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abmodelado farmacocin\u00e9tico y farmacodinamico de ciclofosfamida en pacientes con cancer de mama\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abmodelado farmacocin\u00e9tico y farmacodinamico de ciclofosfamida en pacientes con cancer de mama\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jose Perez Ruixo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/02\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Jimenez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda conde bru javier <\/li>\n<li>Juli\u00e1n Rodriguez larrea (vocal)<\/li>\n<li>esteban Morcillo sanchez (vocal)<\/li>\n<li>azucena Aldaz pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jose Perez Ruixo La estrategia terap\u00e9utica multidiciplinar del cancer de mama ha permitido conseguir un excelente 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