{"id":83311,"date":"2000-11-02T00:00:00","date_gmt":"2000-11-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-diabetes-en-la-digestion-de-hidratos-de-carbono-en-ratas-efectos-de-inhibidores-de-la-digestion-de-hidratos-de-carbono\/"},"modified":"2000-11-02T00:00:00","modified_gmt":"2000-11-02T00:00:00","slug":"influencia-de-la-diabetes-en-la-digestion-de-hidratos-de-carbono-en-ratas-efectos-de-inhibidores-de-la-digestion-de-hidratos-de-carbono","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/influencia-de-la-diabetes-en-la-digestion-de-hidratos-de-carbono-en-ratas-efectos-de-inhibidores-de-la-digestion-de-hidratos-de-carbono\/","title":{"rendered":"Influencia de la diabetes en la digestion de hidratos de carbono en ratas. efectos de inhibidores de la digestion de hidratos de carbono."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel M. Martinez Gonzalez <\/strong><\/h2>\n<p>El intestino delgado juega un papel muy importante en la homeostasisde la glucosa. Numerosos estudios han demostrado que la diabetes tipo 1 influencia los procesos de digesti\u00f3n, absorci\u00f3n y metabolismo intestinal de la glucosa, sin embargo no existen datos sobre efec tos similares en la dibetes tipo 2, por ello el primer objetivo de la tesis doctoral es desarrollar y caracterizar dos modelos de diabetes experimental tipo 2 (modelos n0-stz y n5-stz) en ratas wistar macho. Para ello se miden las concentraciones plasm\u00e1ticas de diferentes par\u00e1metros de control metab\u00f3lico (glucosa, insulina, triglic\u00e9ridos y colesterol total)y en enterocitos aislados se miden las actividades enzim\u00e1ticas: discaridasas intestinales (sacaras y maltsa), fosfotructoquinasa 1(pfk-1) y se realiza un estudio de captaci\u00f3n de glucosa y producci\u00f3n de lactato. el inter\u00e9s del estudio se basa en que el uso de inhibidores de las alfaglucosidasas permite profundizar en los mecanismos fisiol\u00f3gicos y bioqu\u00edmicos de la digesti\u00f3n y absorci\u00f3n intestinal de glucosa en ratas normales y diab\u00e9ticas tipo 2. As\u00ed el segundo objetivo del trabajo es: estudiar la administraci\u00f3n oral, de miglitol (inhibidor de las alfa-glucosidasas, 10 mg\/kg p.C.,21 d\u00edas) sobre los par\u00e1metros biqu\u00edmicos detallados anteriormente y par\u00e1metros de control metab\u00f3lico (peroso corporal, ingesti\u00f3n de agua y de comida) e investigar el efecto de este f\u00e1maco sobre la captaci\u00f3n de glucosa, producci\u00f3n de lactato y sobre las actividades detalladas en el objetivo 1 en enterocitos aislados tras el peri\u00f3do de tratamiento. Las conclusiones del trabajo de investigaci\u00f3n son las siguientes: 1 los modelos de diabetes experimental n0-stz y n5-stz son unos modelos adecuados para la realizaci\u00f3n de estudios sobre la diabetes mellitus tipo 2.2. El intestino delgado sufre modificaciones como un aumento de las actividades discaridasa intestinales y una diminuci\u00f3n estad\u00edusticamente significativa en la actividad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la diabetes en la digestion de hidratos de carbono en ratas. efectos de inhibidores de la digestion de hidratos de carbono.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la diabetes en la digestion de hidratos de carbono en ratas. efectos de inhibidores de la digestion de hidratos de carbono. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel M. Martinez Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/02\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Enrique Campillo \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: yolanda Ga\u00f1\u00e1n presmanes <\/li>\n<li>Mar\u00eda  Luisa Villanueva-pe\u00f1acarrillo molina (vocal)<\/li>\n<li>Mar\u00eda dolores Torres asensio (vocal)<\/li>\n<li>isabel Valverde alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel M. Martinez Gonzalez El intestino delgado juega un papel muy importante en la homeostasisde la glucosa. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,949,5531,817],"tags":[176620,5536,1743,19567,87963,75777],"class_list":["post-83311","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-extremadura","category-fisiologia-gastrointestinal","category-fisiologia-humana","tag-isabel-m-Martinez-gonzalez","tag-isabel-valverde-alonso","tag-jose-enrique-campillo-alvarez","tag-maria-dolores-torres-asensio","tag-maria-luisa-villanueva-penacarrillo-molina","tag-yolanda-ganan-presmanes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83311"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83311\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}