{"id":83399,"date":"2018-03-10T00:07:31","date_gmt":"2018-03-10T00:07:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-funcionales-de-la-proteina-p53-en-la-regulacion-de-la-apoptosis-inducida-por-agentes-genotoxicos\/"},"modified":"2018-03-10T00:07:31","modified_gmt":"2018-03-10T00:07:31","slug":"aspectos-funcionales-de-la-proteina-p53-en-la-regulacion-de-la-apoptosis-inducida-por-agentes-genotoxicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aspectos-funcionales-de-la-proteina-p53-en-la-regulacion-de-la-apoptosis-inducida-por-agentes-genotoxicos\/","title":{"rendered":"Aspectos funcionales de la proteina p53 en la regulacion de la apoptosis inducida por agentes genotoxicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Gutierrez Del Arroyo Valenciano <\/strong><\/h2>\n<p>El estado de la prote\u00edna p53 est\u00e1 implicado en la respuesta a determinados agentes anticancerosos de acci\u00f3n genot\u00f3xica. La prote\u00edna p53 est\u00e1 implicada en la inducci\u00f3n de la apoptosis y deber\u00eda de considerarse a la hora de escoger tratamientos antitumorales. Otros agentes, si bien activan p53, parece que tambi\u00e9n activan mecanismos de apoptosis independientes de p53. los estudios sobre la citotoxicidad de agentes anticancerosos se pueden realizar mediante experimentos in vitro. El tipo de experimentos y la duraci\u00f3n de los mismos son importantes a la hora de valorar los resultados.  la transfecci\u00f3n de p53val135 en baf3 no tiene efecto sobre la sensibilidad de las c\u00e9lulas a drogas. La sobreexpresi\u00f3n de p53wt en las c\u00e9lulas baf3 no provoca inducci\u00f3n del receptor de muerte fas. Parece que es necesario qu p53 est\u00e9 activa para que se induzca esta expresi\u00f3n.  fas tiene un papel en la apoptosis que se produce tras irradiaci\u00f3n con rayos x. El aumento del n\u00famero de receptores en la membrana determina la susceptibilidad a entrar en apoptosis.  la inducci\u00f3n de fas en la membrana tras irradiaci\u00f3n es dependiente de p53. la il3 modula los niveles de prote\u00edna p53 y, por tanto, la entrada de la c\u00e9lula en apoptosis tras irradiaci\u00f3n. La il3 parece que act\u00faa a trav\u00e9s de prote\u00ednas reguladoras de p53.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos funcionales de la proteina p53 en la regulacion de la apoptosis inducida por agentes genotoxicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos funcionales de la proteina p53 en la regulacion de la apoptosis inducida por agentes genotoxicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Gutierrez Del Arroyo Valenciano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Augusto Silva Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ort\u00edz de land\u00e1zuri busca <\/li>\n<li>abelardo L\u00f3pez rivas (vocal)<\/li>\n<li>federico Mayor menendez (vocal)<\/li>\n<li>Javier Rey campos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Gutierrez Del Arroyo Valenciano El estado de la prote\u00edna p53 est\u00e1 implicado en la respuesta a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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