{"id":83414,"date":"2018-03-10T00:07:31","date_gmt":"2018-03-10T00:07:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-biologico-de-la-protea%c2%adna-ataxia-telangiectasia-mutated-atm-en-los-linfocitos-t-inmortalizados-con-el-herpesvirus-saimiri\/"},"modified":"2018-03-10T00:07:31","modified_gmt":"2018-03-10T00:07:31","slug":"papel-biologico-de-la-protea%c2%adna-ataxia-telangiectasia-mutated-atm-en-los-linfocitos-t-inmortalizados-con-el-herpesvirus-saimiri","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-biologico-de-la-protea%c2%adna-ataxia-telangiectasia-mutated-atm-en-los-linfocitos-t-inmortalizados-con-el-herpesvirus-saimiri\/","title":{"rendered":"Papel biol\u00f3gico de la prote\u00edna ataxia-telangiectasia mutated (atm) en los linfocitos t inmortalizados con el herpesvirus saimiri"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rivero Carmena Miguel Eduardo <\/strong><\/h2>\n<p>En la ataxia-telangiectasia (at) se hanobservado defectos en el sistema inmunol\u00f3gico tanto a nivel humoral (b) como celular (t). Como consecuencia, los enfermos at est\u00e1n predispuestos a sufrir infecciones sinopulmonares. los mecanismos patog\u00e9nicos de esta enfermedad son todav\u00eda desconocido. en este trabajo se hanexplorado los efectos de la ausencia del gen atm en c\u00e9lulas del linaje t aisladas de 13 enfermos at con defectos probados en sus c\u00e9lulas t, mediante la inmortalizaci\u00f3nde linfocitos t cd4+ y cd8+ con herpesvirus saimiri, y el an\u00e1lisis de su comportamiento funcional en comparaci\u00f3n concontroles sanos. Se han analizado varios par\u00e1metros funcionales enrespeusta a est\u00edmulos de membrana (anti-cd3, il2) y transmembrana (pma m\u00e1s ionomician): 1) movilizaci\u00f3n de calcio intracelular, 2) inducci\u00f3nde mol\u00e9culas de activaci\u00f3n (cd71, cd154, cd69, y cd25). 3) s\u00edntesis de citocinas (il2 y tnfa) y4) proliferaci\u00f3n celular. Hemos visto que todos estos procesos, tempranos y tard\u00edos, son normales en las c\u00e9lulas t atm inmortalizadas lo que indica que atm no es necesar\u00eda para su inducci\u00f3n. Como era de esperar, los linfociots t atm muestranun incremento de la sensibilidad a la radiaci\u00f3n en ensayos de s\u00edntesis de adn radioresistente y de supervivencia.  en contraste a los datos publicados recientemente para los linfocitos b, nuestros resultados indican que los linfocitos t maduros de los enfermos at no presentan defectos intr\u00ednsecos en su funci\u00f3n inmune. Por lo tanto, los defectos descritos en los linfocitos t podr\u00edan ser debidos a un defecto en el desarrollo o a la presencia de factores supresores in vivo. Los linfocitos t inmortalizados podr\u00edan ayudar a la comprensi\u00f3n al papel de atm en los diferentes tipos celulares y al desarrollo de terapias frente a la inmunodeficiencias de los enfermos at.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel biol\u00f3gico de la prote\u00edna ataxia-telangiectasia mutated (atm) en los linfocitos t inmortalizados con el herpesvirus saimiri<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel biol\u00f3gico de la prote\u00edna ataxia-telangiectasia mutated (atm) en los linfocitos t inmortalizados con el herpesvirus saimiri <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rivero Carmena Miguel Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ramon Regueiro  Gonzalez Barros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>ignacio Pascual castroviejo (vocal)<\/li>\n<li>gumersindo Fontan casriego (vocal)<\/li>\n<li>Jos\u00e9 Luis Subiza  garrido-lestache (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rivero Carmena Miguel Eduardo En la ataxia-telangiectasia (at) se hanobservado defectos en el sistema inmunol\u00f3gico tanto a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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