{"id":83501,"date":"2018-03-10T00:07:39","date_gmt":"2018-03-10T00:07:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-ciclosporina-a-en-la-modulacion-de-la-inflamacion-y-la-fibrogenesis-en-la-artritis-experimental\/"},"modified":"2018-03-10T00:07:39","modified_gmt":"2018-03-10T00:07:39","slug":"efecto-de-la-ciclosporina-a-en-la-modulacion-de-la-inflamacion-y-la-fibrogenesis-en-la-artritis-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-ciclosporina-a-en-la-modulacion-de-la-inflamacion-y-la-fibrogenesis-en-la-artritis-experimental\/","title":{"rendered":"Efecto de la ciclosporina a en la modulacion de la inflamacion y la fibrogenesis en la artritis experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Benito Guzman M. Jes\u00fas <\/strong><\/h2>\n<p>La artritis reumatoide (ar) se caracteriza por la hiperplasia de la membrana sinovial, la infiltraci\u00f3n de c\u00e9lulas inflamatorias y la fibrosis. La ciclosporina (csa) es un agente inmonosupresor que tradicionalmente se ha utilizado como tratamiento previo a los transplantes. Hoy en d\u00eda csa se utiliza cada vez m\u00e1s en pacientes con ar para controlar la progresi\u00f3n de la enfermedad, aunque se conoce poco acerca de su efecto sobre la membrana sinovial. En el presente trabajo se ha utilizado un modelo de artritis por adyuvante en conejos para estudiar la acci\u00f3n de la csa sobre las lesiones sinoviales. este modelo experimental presenta una patolog\u00eda muy similar a la de la ar, no solo en sus efectos inflamatorios, sino tambi\u00e9n en el dep\u00f3sito de prote\u00ednas de matriz. El estudio histopatol\u00f3gico demostr\u00f3 que la administraci\u00f3n de csa(10 mg\/kg\/d\u00eda) disminuyo la hiperplasia de la membrana, el infiltrado de macr\u00f3fagos y la proliferaci\u00f3n sinovial. Entre las acciones antiinflamatorias de la csa se encontraba la inhibici\u00f3n en la producci\u00f3n de cox-2, la ciclooxigenasa inducible responsable de la s\u00edntesis de pge2. El tratamiento tambi\u00e9n consigui\u00f3 reducir la exprexi\u00f3n y s\u00edntesis de dos de los principales factores pro-fibrog\u00e9nicos, el tgf-b y el pdgf, as\u00ed como el ac\u00famulo de las prote\u00ednas de matriz col\u00e1genos i, iii y fibronectina. Mediante ensayos in vitro se mostr\u00f3 que los sinoviocitos respond\u00edan de forma diferente a las acciones de la csa en la expresi\u00f3n de tgf-b dependiendo de que se tratara de c\u00e9lulas sanas o artr\u00edticas, lo que explicar\u00eda la ausencia de fibrosis en los animales tratados. Por otra parte, en cuanto a los mecanismos implicados, en este trabajo se ha visto que la csa no modula la activaci\u00f3n de los factores nucleares nk-kb, ap-1 ni nf-at en la membrana sinovial, y que incluso es capaz de activarlos en los sinoviocitos cultivados, por lo que debe ejercer sus efectos a nivel post-transcripcional. Adem\u00e1s, son tanto los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la ciclosporina a en la modulacion de la inflamacion y la fibrogenesis en la artritis experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la ciclosporina a en la modulacion de la inflamacion y la fibrogenesis en la artritis experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Benito Guzman M. Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/02\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>beaumont Cuenca Herrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Valdivieso amate <\/li>\n<li>Manuel Oya otero (vocal)<\/li>\n<li>federico Navarro sarabia (vocal)<\/li>\n<li>arturo Rodr\u00edguez de la serna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benito Guzman M. Jes\u00fas La artritis reumatoide (ar) se caracteriza por la hiperplasia de la membrana sinovial, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,9,156,1323,17],"tags":[47056,49262,176935,47055,14429,2097],"class_list":["post-83501","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-medicas","category-patologia","category-patologia-experimental","category-quimica","tag-arturo-rodriguez-de-la-serna","tag-beaumont-cuenca-herrero","tag-benito-guzman-m-jesus","tag-federico-navarro-sarabia","tag-fernando-valdivieso-amate","tag-manuel-oya-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83501"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83501\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}