{"id":8353,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/anticuerpos-antigangliosidos-en-enfermedades-neuromusculares-y-posible-papel-de-los-linfocitos-b-cd5-en-la-esclerosis-lateral-amiotrofica\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"anticuerpos-antigangliosidos-en-enfermedades-neuromusculares-y-posible-papel-de-los-linfocitos-b-cd5-en-la-esclerosis-lateral-amiotrofica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/anticuerpos-antigangliosidos-en-enfermedades-neuromusculares-y-posible-papel-de-los-linfocitos-b-cd5-en-la-esclerosis-lateral-amiotrofica\/","title":{"rendered":"Anticuerpos antigangliosidos en enfermedades neuromusculares y posible papel de los linfocitos b cd5+ en la esclerosis lateral amiotrofica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nicolau Ortiz Castellon <\/strong><\/h2>\n<p>Se han encontrado anticuerpos antigangliosido en ciertas enfermedades neuromusculares. En el sgb se han asociado a formas axonales y a serolog\u00eda contra c.Jejuni. Se han presentado sgb despues de gangliosidos parenterales. La respuesta cronica antigm1, que es de classe igm y con titulos estables, podria estar producida por linfocitos b cd5+, relacionados con enfermedades autoinmunes.  objetivos: evaluar la respuesta antigangliosido en pacientes con ela, amp, pnp, sgb y controles. Comparar el porcentaje de linfocitos b cd5+ entre pacientes con ela y controles y determinar su correlacion con el titulo de anticuerpos. Metodos: elisa, cromatografia en capa fina, citometria de flujo, fijacion de complemento y inmunohistoquimica. Resultados: los porcentajes de positividad de clase igm antigm1 han sido los siguientes:  controles: 9.5%, ela: 11% (ns), amp: 16.7% (p=0.0085), sgb: 21.4% (p=0.047), pnp: 13.5% (ns), nmm:0% (ns), s-s:  7.9% (ns), mg: 0% (ns). Solo dos grupos muestran anticuerpos antigm1 de clase igg: 1) sgb (31%, p=0.0001) y 2) amp (13%, p=0.003). Todos los sgb post-gangliosidos parenterales mostraron anticuerpos antigangliosido por solo el 35% de sgb convencionales y el 0% de controles pretratados. Los anticuerpos se asocian a formas axonales y a reactividad contra c. Jejuni. Conclusiones: no se han encontrado pruebas que apoyen una etiolog\u00eda autoinmune en la ela. La amp se ha asociado a anticuerpos antigm1, en cuyo caso los pacientes pueden ser tratados. Los gangliosidos parenterales pueden inducir la produccion de anticuerpos y estos desencadenar una neuropatia motora axonal aguda. Estos anticuerpos pueden jugar un papel en la lesion axonal en el sgb<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anticuerpos antigangliosidos en enfermedades neuromusculares y posible papel de los linfocitos b cd5+ en la esclerosis lateral amiotrofica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anticuerpos antigangliosidos en enfermedades neuromusculares y posible papel de los linfocitos b cd5+ en la esclerosis lateral amiotrofica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nicolau Ortiz Castellon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Illa Sendra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: LLuis Masana Marin <\/li>\n<li> Olive Plana Josep Mar\u00eda (vocal)<\/li>\n<li>Carles Roig Arnall (vocal)<\/li>\n<li>Jes\u00fas Pradas Orozco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nicolau Ortiz Castellon Se han encontrado anticuerpos antigangliosido en ciertas enfermedades neuromusculares. En el sgb se han [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,35,9,1737,139,1880],"tags":[13984,29365,13788,14099,29364,29366],"class_list":["post-8353","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-medicina-interna","category-neurologia","tag-carles-roig-arnall","tag-isabel-illa-sendra","tag-jesus-pradas-orozco","tag-lluis-masana-marin","tag-nicolau-ortiz-castellon","tag-olive-plana-josep-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=8353"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8353\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=8353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=8353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=8353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}