{"id":83556,"date":"2018-03-10T00:07:43","date_gmt":"2018-03-10T00:07:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-fenotipica-de-ratones-geneticamente-deficientes-en-telomerasa\/"},"modified":"2018-03-10T00:07:43","modified_gmt":"2018-03-10T00:07:43","slug":"caracterizacion-fenotipica-de-ratones-geneticamente-deficientes-en-telomerasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-fenotipica-de-ratones-geneticamente-deficientes-en-telomerasa\/","title":{"rendered":"Caracterizacion fenotipica de ratones geneticamente deficientes en telomerasa."},"content":{"rendered":"

Tesis doctoral de Eloisa Herrera Gonzalez De Molina <\/strong><\/h2>\n

– el acortamiento telom\u00e9rico en rat\u00f3n muestra una correlaci\u00f3n directa con la suervivencia del organismo. Los ratones que carecen del gen que codifica para el rna de la telomerasa en un fondo gen\u00e9tico con los tel\u00f3meros cortos, exhiben un fenotipo m\u00e1s acusado y m\u00e1s temprano que los ratones que tienen una longitud telom\u00e9rica inicial m\u00e1s larga. – el cierre del tubo neural durante el desarrollo embrionario es uno de los procesos m\u00e1s sensibles al acortamiento telom\u00e9rico. El acortamiento teolom\u00e9rico cr\u00edtico durante este proceso puede desencadenar defectos en el embri\u00f3n tales como asimetr\u00eda bilateral del cerebro o defectos en el cierre del tubo neural. – en ausencia de telomerasa, el rat\u00f3n desarrolla un fenotipo similar al de envejecimiento prematuro en los \u00f3rganos relaccionados con una proliferaci\u00f3n celular masiva tales como sistema digestivo, sistema inmune y la l\u00ednea germinal. – ratones que carecen de actividad telomerasa y que tienen tel\u00f3meros cortos muestran un incremento en la aparici\u00f3n de neoplasias, principalmente en los \u00f3rganos que tambi\u00e9n mostraban defectos proliferativos tales como el sistema inmune, digestivo y l\u00ednea germinal. – en ratones salvajes la elongaci\u00f3n del tel\u00f3mero que tiene lugar durante la formaci\u00f3n de los centros germinales despu\u00e9s de una inmunizaci\u00f3n se debe a la activaci\u00f3n de la telomerasa, ya que estos ratones deficientes en telomerasa no muestran tal alargamiento de la longitud telom\u00e9rica. – el acortamiento del tel\u00f3mero afecta a la capacidad de formaci\u00f3n de los centros germinales en los bazos de rat\u00f3n en respuesta a inmunizaci\u00f3n. – el acortamiento telom\u00e9rico que sufren los esplenocitos de las c\u00e9lulas de ratones sin telomerasa provoca un defecto en la respuesta humoral como reacci\u00f3n a un ant\u00edgeno. – las c\u00e9lulas de bazo derivadas de ratones sin telomerasa de las \u00faltimas generaciones que han sido inmunizados muestran una longitud telom\u00e9rica comparable a la de los r<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abCaracterizacion fenotipica de ratones geneticamente deficientes en telomerasa.<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion fenotipica de ratones geneticamente deficientes en telomerasa. <\/li>\n
  • Autor:<\/strong>\u00a0 Eloisa Herrera Gonzalez De Molina <\/li>\n
  • Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2000<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Mar\u00eda Antonia Blasco Marhuenda<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: margarita Salas <\/li>\n
        • Mar\u00eda no Barbacid montalb\u00e1n (vocal)<\/li>\n
        • alfredo Villasante atienza (vocal)<\/li>\n
        • (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Eloisa Herrera Gonzalez De Molina – el acortamiento telom\u00e9rico en rat\u00f3n muestra una correlaci\u00f3n directa con la […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,35],"tags":[10596,177014,160595,42608,42609],"class_list":["post-83556","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-ciencias-de-la-vida","tag-alfredo-villasante-atienza","tag-eloisa-herrera-gonzalez-de-molina","tag-margarita-salas","tag-maria-antonia-blasco-marhuenda","tag-maria-no-barbacid-montalban"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83556"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83556\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}