{"id":83677,"date":"2000-08-03T00:00:00","date_gmt":"2000-08-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/correlacion-entre-parametros-morfometricos-proliferacion-celular-y-expresion-del-oncogen-p-53-en-la-secuencia-andonoma-carcinoma-de-colon-y-recto\/"},"modified":"2000-08-03T00:00:00","modified_gmt":"2000-08-03T00:00:00","slug":"correlacion-entre-parametros-morfometricos-proliferacion-celular-y-expresion-del-oncogen-p-53-en-la-secuencia-andonoma-carcinoma-de-colon-y-recto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/correlacion-entre-parametros-morfometricos-proliferacion-celular-y-expresion-del-oncogen-p-53-en-la-secuencia-andonoma-carcinoma-de-colon-y-recto\/","title":{"rendered":"Correlacion entre par\u00e1metros morfom\u00e9tricos proliferaci\u00f3n celular y expresi\u00f3n del oncogen p-53 en la secuencia andonoma carcinoma de colon y recto."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco JavierDel Rio Lafuente <\/strong><\/h2>\n<p>Introduccion:  los adenomas representan los prsecursores biol\u00f3gicos de la mayor parte de los carcinomas colorectales. La secuencia adenoma-cardinoma esta surgida en datos morfol\u00f3gicos, consolidada por datos cl\u00ednicos y epidemiol\u00f3gicos y confirmada por etudios biomolecualres. El rpn\u00f3stico del carcinoma colorrectal no solo va a depender de la difusi\u00f3n a los linfon\u00f3dulos regionales sino tambi\u00e9n se va a correlacionar con otros factores o indicadores biol\u00f3gicos de malignidad actualmente en estudio y de los cuales los m\u00e1s significativos son: el grado morfol\u00f3gico de diferenciaci\u00f3n, la cin\u00e9tica celular y la expresi\u00f3n de oncogenes y genes supresores.  planteamiento de problema:  en el presente estudio se pretende introducir la nueva informaci\u00f3n disponible, procedente de las t\u00e9cnicas patol\u00f3gicas convencionales, morfom\u00e9tricas, e inmunohistoqu\u00edmicas de proliferaci\u00f3n celular y de detecci\u00f3n de la expresi\u00f3n del oncog\u00e9n p53, para correlacionar os nuevos par\u00e1metros cuantitativos, con otras varialbes, cl\u00ednicas y patol\u00f3gicas, que han demostrado su importancia en el pron\u00f3sitco de los adenomas colo-rectales para intentar mejorar la predicci\u00f3n de la evoluci\u00f3n de los enfermos con adenocarcinoma de colon y recto (estadio patol\u00f3gico).  material y metodo:  en el presente estudio se han seleccionado, con car\u00e1cter prospectivo, durante el per\u00edodo comprendido entre 1994 y 1997, 100 casos consecutivos, 50 adenomas y 50 adenocarcinomas de intestino grueso, procedentes del servicio de cirug\u00eda general y anatonm\u00eda patol\u00f3gica del hospital universitario \u00abvirgen macarena\u00bb y de sevvilla. El control ha sido recogido de zonas no afectadas de los mismos pacientes intervenidos por dichos des\u00f3rdenes. Se ha realizado una valoraci\u00f3ncl\u00ednica, una valoraci\u00f3n histol\u00f3gica convencional, un estudio morfom\u00e9trico y un estudio inmunohistoq\u00faimico para determinar el indice de proliferaci\u00f3n celular utilizando el ac monocional mib-1 y la expresi\u00f3n d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Correlacion entre par\u00e1metros morfom\u00e9tricos proliferaci\u00f3n celular y expresi\u00f3n del oncogen p-53 en la secuencia andonoma carcinoma de colon y recto.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Correlacion entre par\u00e1metros morfom\u00e9tricos proliferaci\u00f3n celular y expresi\u00f3n del oncogen p-53 en la secuencia andonoma carcinoma de colon y recto. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco JavierDel Rio Lafuente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ortega Bevi\u00e1 Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fuente perucho agust\u00edn de la <\/li>\n<li> Los cortales abril Jes\u00fas (vocal)<\/li>\n<li>Antonio Jim\u00e9nez Garc\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Antonio Bondia navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco JavierDel Rio Lafuente Introduccion: los adenomas representan los prsecursores biol\u00f3gicos de la mayor parte de los 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