{"id":83694,"date":"2000-09-03T00:00:00","date_gmt":"2000-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-regulacion-y-sensibilidad-farmacologica-de-diferentes-subtipos-de-receptores-nicotinicos-neuronales\/"},"modified":"2000-09-03T00:00:00","modified_gmt":"2000-09-03T00:00:00","slug":"funcion-regulacion-y-sensibilidad-farmacologica-de-diferentes-subtipos-de-receptores-nicotinicos-neuronales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/funcion-regulacion-y-sensibilidad-farmacologica-de-diferentes-subtipos-de-receptores-nicotinicos-neuronales\/","title":{"rendered":"Funcion, regulacion y sensibilidad farmacologica de diferentes subtipos de receptores nicotinicos neuronales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Javier Herrero Rodriguez <\/strong><\/h2>\n<p>En las c\u00e9lulas cromafines de la m\u00e9dula adrenal, la liberaci\u00f3n exocit\u00f3tica de catecolaminas y del restante contenido intravesicular (cromograninas, atp, p\u00e9ptidos opioides) se produce como consecuencia de la liberaci\u00f3n de acetilcolina (ach) desde el nervio espl\u00e1cnico. La ach liberada activa diferentes subtipos de receptores nicot\u00ednicos (nachrs) presentes en las c\u00e9lulas cromaf\u00ednes, lo que produce la depolarizaci\u00f3n celular, la entrada de iones ca2+ a trav\u00e9s de los canales de calcio voltaje-dependientes (ccvd), y la consiguiente secreci\u00f3n de catecolaminas al torrente sangu\u00edneo. Sin embargo, aunque en t\u00e9rminos generales se conoce toda la secuencia de eventos que conducen a la secreci\u00f3n de catecolaminas, hay ciertos puntos de proceso que permanecen a\u00fan por clarificar. En esta tesis nos hemos planteado los siguientes objetivos: i) \u00c2\u00bfparticipa el nachr del subtipo de la c\u00e9lula cromaf\u00edn en el control de la secreci\u00f3n de catecolaminas?; Ii) \u00c2\u00bfpuede el p\u00e9ptido catestatina, procedente de la proteolisis de la cromogranina a, ser un modulador end\u00f3geno de los diversos subtipos de nachrs?; Iii) \u00c2\u00bfcu\u00e1l es la sensibilidad de los diferentes subtipos de nachrs neuronales a f\u00e1rmacos y toxinas, tradicionalmente considerados como bloqueantes espec\u00edficos de los ccvd? Para responder estas cuestiones, hemos utilizado, de forma complementaria, dos modelo experimentales como son: los ovocitos de rana xenopus laevis, donde expresamos diferentes subtipos de nachrs, y la c\u00e9lula cromaf\u00edn.  las conclusiones fundamentales obtenidas son: 1) el nachr del subtipo al contrario de lo que se pensaba, participa en el control de la secreci\u00f3n de catecolaminas, junto con el receptor. 2) la catestatina bloquea, de manera potente, todos los subtipos de nachrs ensayados. 3) los f\u00e1rmacos y toxinas antagonistas de los ccvd, tambi\u00e9n bloquean diversos subtipos de nachrs, principalmente aquellos heterom\u00e9ricos. 4) se observaron importantes diferencias en el mecan<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion, regulacion y sensibilidad farmacologica de diferentes subtipos de receptores nicotinicos neuronales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion, regulacion y sensibilidad farmacologica de diferentes subtipos de receptores nicotinicos neuronales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Javier Herrero Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Montiel L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Mar\u00eda Trifaro jose (vocal)<\/li>\n<li>Francisco Sala merchan (vocal)<\/li>\n<li>Jaime Renart pita (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Javier Herrero Rodriguez En las c\u00e9lulas cromafines de la m\u00e9dula adrenal, la liberaci\u00f3n exocit\u00f3tica de catecolaminas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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