{"id":83722,"date":"2000-10-03T00:00:00","date_gmt":"2000-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/envejecimiento-y-dishemopoyesis\/"},"modified":"2000-10-03T00:00:00","modified_gmt":"2000-10-03T00:00:00","slug":"envejecimiento-y-dishemopoyesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/envejecimiento-y-dishemopoyesis\/","title":{"rendered":"Envejecimiento y dishemopoyesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia M Fernandez  Ferrero <\/strong><\/h2>\n<p>Hemos evaluado los hallazgos cito-histol\u00f3gicos de dishemopoyesis en muestras de m\u00e9dula \u00f3sea (mo) obtenidas de personas sanas mayores de 50 a\u00f1os sincitopenias en sangre perif\u00e9rica (grupo control) y los hemos comparado con pacientes diagnosticados de s\u00edndrome mielodispl\u00e1sico (smd). Las personas incluidas en el grupo control mostraron hallazgos diseritropoy\u00e9ticos y disgranulopoy\u00e9ticos hasta en el 15% y 27%, respectivamente, de las c\u00e9lulas consideradas (p90), superponi\u00e9ndose en parte con los hallazgos de los pacientes diagnosticados de smd. Evaluamos tambi\u00e9n la concordancia interobservador en los hallazgos citol\u00f3gicos, observando que el recuento de blastos y de sideroblastos patol\u00f3gicos en mo son los par\u00e1metros donde la concordancia es mayor y por tanto, los m\u00e1s reproducibles. Incluyendo ambas variables, dise\u00f1amos un nuevo algoritmo diagn\u00f3sitco que fue verificado en 613 pacientes procedentes de diferentes centros hospitalarios espa\u00f1oles y que demostr\u00f3 su utilidad para mejorar la reproductibilidad en el diagn\u00f3stico de los smd (\u00e1rea bajo la curva roc: 0,923). tambi\u00e9n hemos cuantificado los hallazgos dishemopoy\u00e9ticos en la mo de personas sanas menores de 50 a\u00f1os sincitopenias. Detectamos una correlaci\u00f3n positiva estad\u00edsticamente significativa entre la edad y los hallazgos diseritropoy\u00e9ticos y disgranulopoy\u00e9ticos (r=+0,70. P-0,001 y r=+0,275, p-0,044, respectivamente), as\u00ed como una correlaci\u00f3n negativa entre la edad y el recuentro de blastos en mo (r=0,329, p= 0,016). Despu\u00e9s de considerar otras covariables, se puso de manifiesto que los fumadores, a cualquier edad, mostraban en su mo una proporci\u00f3n de hallazgos diseritropoy\u00e9cticos, 3,73% superior y un porcentaje de blastos 0,28% mayor que los no fumadores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Envejecimiento y dishemopoyesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Envejecimiento y dishemopoyesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia M Fernandez  Ferrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Ramos Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Lopez Borrasca <\/li>\n<li>Luis Hernandez Nieto (vocal)<\/li>\n<li>Guillermo Sanz Santillana (vocal)<\/li>\n<li>Teresa Vallespi Sole (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia M Fernandez Ferrero Hemos evaluado los hallazgos cito-histol\u00f3gicos de dishemopoyesis en muestras de m\u00e9dula \u00f3sea (mo) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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