{"id":83767,"date":"2018-03-10T00:07:55","date_gmt":"2018-03-10T00:07:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-a-largo-plazo-de-hepatitis-cronica-por-virus-b-en-ninos-y-adolescentes-despues-de-seroconversion-a-anti-hbe\/"},"modified":"2018-03-10T00:07:55","modified_gmt":"2018-03-10T00:07:55","slug":"evolucion-a-largo-plazo-de-hepatitis-cronica-por-virus-b-en-ninos-y-adolescentes-despues-de-seroconversion-a-anti-hbe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evolucion-a-largo-plazo-de-hepatitis-cronica-por-virus-b-en-ninos-y-adolescentes-despues-de-seroconversion-a-anti-hbe\/","title":{"rendered":"Evoluci\u00f3n a largo plazo de hepatitis cr\u00f3nica por virus b en ni\u00f1os y adolescentes despu\u00e9s de seroconversi\u00f3n a anti-hbe."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuela Otero Fraguas <\/strong><\/h2>\n<p>Objetivo  la hepatitis cr\u00f3nica b, en ni\u00f1os, puede evolucionar a cirrosis y hepatocarcinoma, por o que es necesario un estrico seguimiento. La evoluci\u00f3n a largo plazo, despu\u00e9s de la seroconversi\u00f3n a anti-hbe y normalidad de transaminasas, se conoce escasamente. El objetivo de este estudio es conocer la evoluci\u00f3n cl\u00ednica, bioqu\u00edmica, virol\u00f3gica e histol\u00f3gica a largo plazo, en un suficiente n\u00famero de pacientes, despu\u00e9s de seroconvertir a anti-hbe y normalizar las transaminasas.  pacientes y m\u00e9todos  se incluyeron 103 ni\u00f1os (edad 6,4-3,3 a\u00f1os) con hepatitis cr\u00f3nica b comprobada histol\u00f3gicamente. Se clasificaron en 2 grupos tratado; n=7 5, que recibieron tratamiento con interfer\u00f3n alfa (360-720 mu im2,12-24 semanas). grupo no tratado; n=28. El tiempo de seguimiento desde la serconversi\u00f3n a anti-hbe y normalidad de las transaminasas fue de 6,3-3,2 a\u00f1os (0,6-12,5 a\u00f1os) realiz\u00e1ndose controles cl\u00ednicos, bioqu\u00edmicos, virol\u00f3gicos cada 6 meses. En caso de nuevo incremento de transaminasas, se estudiaron marcadores del vbh, de otros virus hepatotropos, del vih y anticuerpos de autoinmunidad. al final del seguimiento se realiz\u00f3 nueva biopsia en 86(83%) para estudio morfol\u00f3gico y biolog\u00eda molecular.  resultados  durante el seguimiento posterior a la seroconversi\u00f3n a anti-hbe y normalidad de transaminasas no se observaron diferencias significativas en ambos grupos. seroconvirtieron a anti-hbs cinco ni\u00f1os (5%); 13 ni\u00f1os tuvieron incremento transitorio de alt y, en ocho m\u00e1s, este aumento fue permanente. En uno de estos ocho apareci\u00f3 antidelta en suero y en otro, arn-vch(+). Hubo un paciente (1%) que tuvo reactivaci\u00f3n viral, con adn-vbh y aghbe (+). La biopsia final mejores significativamente en los dos grupos.  en la biopsias realizadas 12 meses despu\u00e9s de la seroconversi\u00f3n la mejor\u00eda es significativamente mayor que en las hechas antes. En todas las biopsias se detect\u00f3 adn-vbh pro pcr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evoluci\u00f3n a largo plazo de hepatitis cr\u00f3nica por virus b en ni\u00f1os y adolescentes despu\u00e9s de seroconversi\u00f3n a anti-hbe.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evoluci\u00f3n a largo plazo de hepatitis cr\u00f3nica por virus b en ni\u00f1os y adolescentes despu\u00e9s de seroconversi\u00f3n a anti-hbe. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuela Otero Fraguas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Ruiz Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Hern\u00e1ndez rodr\u00edguez <\/li>\n<li> Pruduzain sosa Jos\u00e9 Carlos (vocal)<\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<li>Luis Antonio Alvarez-sala walther (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuela Otero Fraguas Objetivo la hepatitis cr\u00f3nica b, en ni\u00f1os, puede evolucionar a cirrosis y hepatocarcinoma, por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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