{"id":83796,"date":"2018-03-10T00:08:00","date_gmt":"2018-03-10T00:08:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunocomplejos-circulantes-y-mecanismos-de-inmunosupresion-en-la-infeccion-por-el-virus-de-inmunodeficiencia-humana\/"},"modified":"2018-03-10T00:08:00","modified_gmt":"2018-03-10T00:08:00","slug":"inmunocomplejos-circulantes-y-mecanismos-de-inmunosupresion-en-la-infeccion-por-el-virus-de-inmunodeficiencia-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inmunocomplejos-circulantes-y-mecanismos-de-inmunosupresion-en-la-infeccion-por-el-virus-de-inmunodeficiencia-humana\/","title":{"rendered":"Inmunocomplejos circulantes y mecanismos de inmunosupresion en la infeccion por el virus de inmunodeficiencia humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Aceituno Terradillos <\/strong><\/h2>\n<p>El vih es capaz de producir una profunda depleci\u00f3n de c\u00e9lulas t cd4+ en el sistema inmune y los mecanismos por los cuales lo consigue contin\u00faan a\u00fan en estudio.  en esta tesis se estudia la capacidad de los inmunocomplejos circulantes procedentes de pacientes infectados por el vih para inducir distintos mecanismos de inmunosupresi\u00f3n en linfocitos cd4+. Estos inmunocomplejos est\u00e1n elevados en la mayor\u00eda de los pacientes infectados, sin que se encuentre una patolog\u00eda asociada a su presencia, su composici\u00f3n es fundamentalmente gp 120\/anti-gp 120 y pueden unirse al receptor cd4 de los linfocitos. Esta uni\u00f3n permite que los inmunocomplejos puedan inducir en linfocitos procedentes de sujetos sanos estimulados con pha apoptosis y tambi\u00e9n una inhibici\u00f3n de la proliferaci\u00f3n mediante la inhibici\u00f3n de la traslocaci\u00f3n del factor de la transcripci\u00f3n nf-kb. La acci\u00f3n de estos inmunocomplejos sobre linfocitos estimulados de pacientes infectados por el vih distinta, en este caso se produce un aumento de la traslocaci\u00f3n de nf-kb con el consiguiente aumento de la replicaci\u00f3n viral. Se propone entonces un modelo para explicar la posible acci\u00f3n de los inmunocomplejos enla infecci\u00f3n por vih: al comienzo de la infecci\u00f3n los inmunocomplejos producir\u00edan una inhibici\u00f3nd e la activaci\u00f3n de los linfocitos cd4 induciendo en ellos un estado de anergia y su posterior muerte por apoptosis, sin embargo, en la infecci\u00f3n avanzada los inmunocomplejos producir\u00edan un aumento de la replicaci\u00f3n viral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunocomplejos circulantes y mecanismos de inmunosupresion en la infeccion por el virus de inmunodeficiencia humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunocomplejos circulantes y mecanismos de inmunosupresion en la infeccion por el virus de inmunodeficiencia humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Aceituno Terradillos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Garcia Delgado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li> Mu\u00f1oz hernandez M\u00aa angeles (vocal)<\/li>\n<li> Gorgolas hernandez mora Miguel de (vocal)<\/li>\n<li>Manuel Fresno escudero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Aceituno Terradillos El vih es capaz de producir una profunda depleci\u00f3n de c\u00e9lulas t cd4+ en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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