{"id":83819,"date":"2018-03-10T00:08:00","date_gmt":"2018-03-10T00:08:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-evaluacion-de-formas-galenicas-para-el-tratamiento-de-la-brucelosis\/"},"modified":"2018-03-10T00:08:00","modified_gmt":"2018-03-10T00:08:00","slug":"desarrollo-y-evaluacion-de-formas-galenicas-para-el-tratamiento-de-la-brucelosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-y-evaluacion-de-formas-galenicas-para-el-tratamiento-de-la-brucelosis\/","title":{"rendered":"Desarrollo y evaluaci\u00f3n de formas gal\u00e9nicas para el tratamiento de la brucelosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sandra Prior Darbonnens <\/strong><\/h2>\n<p>La brucelosis es una enfermedad producida por brucella, bacteria intracelular facultativa, con importantes repercusiones socioecon\u00f3micas. Constituye un grave problema de salud animal y humana, principalmente en areas rurales. los tratamientos actuales son largos y combinan diversos antibi\u00f3ticos, pero su eficacia es limitada y son frecuentes las reca\u00eddas debido a su pobre penetraci\u00f3n intracelular, y a menudo, al incumplimiento del paciente. por lo tanto, el desarrollo de sistemas que puedan alcanzar la localizaci\u00f3n intracelular y permitan la liberaci\u00f3n controlada de antibioticos reduciendo el n\u00famero de dosis y la toxicidad asociada, supondr\u00eda una importante mejora.  microparticulas y liposomas administrados parenteralmente son reconocidos como material extra\u00f1o al organismo, y son capturados por el sistema monocito-macrof\u00e1gico. este hecho supone una ventaja a la hora de tratar enfermedades intracelulares como la brucelosis. En este sentido, polimeros biodegradables, basados en acido lactico(pla) y copol\u00edmeros con el \u00e1cido glic\u00f3lico(plga), permitieron la encapsulaci\u00f3n de gentamicina. Se desarrollaron microparticulas de unas 3 um de tama\u00f1o medio con encapsulaciones de hasta un 45% y liberacion controlada del antibi\u00f3tico. La eficacia de encapsulaci\u00f3n y el perfil de liberaci\u00f3n se relacionaron con las caracteristicas fisico-quimicas del pol\u00edmero y del antibiotico. Las caracteristicas de las particulas fueron adecuadas para ser eficientemente capturadas por monocitos j774, y adem\u00e1s estimular significativamente la actividad tanto de monocitos humanos sanguineos como de monocitos tumorales de la linea celular. La eficacia de las formulaciones in vitro fue evaluada en cultivos celulares de monocitos infectados con brucella abortus. Los resultados obtenidos demostraron que la gentamicina encapsulada en microparticulas de plga disminuy\u00f3 el numero de bacterias intracelulares (hasta tres logaritmos) respecto a celulas no tratadas. si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y evaluaci\u00f3n de formas gal\u00e9nicas para el tratamiento de la brucelosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y evaluaci\u00f3n de formas gal\u00e9nicas para el tratamiento de la brucelosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sandra Prior Darbonnens <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gamazo De La Rasilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Luis D\u00edaz Garc\u00eda <\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<li> Alonso alonso Mar\u00eda  Jos\u00e9 (vocal)<\/li>\n<li>Javier Ariza castresana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandra Prior Darbonnens La brucelosis es una enfermedad producida por brucella, bacteria intracelular facultativa, con importantes repercusiones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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