{"id":83839,"date":"2018-03-10T00:08:00","date_gmt":"2018-03-10T00:08:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-autorreceptores-serotonergicos-en-la-accion-de-los-farmacos-antidepresivos-diferencias-entre-las-va%c2%adas-del-rafe-dorsal-y-medial\/"},"modified":"2018-03-10T00:08:00","modified_gmt":"2018-03-10T00:08:00","slug":"papel-de-los-autorreceptores-serotonergicos-en-la-accion-de-los-farmacos-antidepresivos-diferencias-entre-las-va%c2%adas-del-rafe-dorsal-y-medial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-autorreceptores-serotonergicos-en-la-accion-de-los-farmacos-antidepresivos-diferencias-entre-las-va%c2%adas-del-rafe-dorsal-y-medial\/","title":{"rendered":"Papel de los autorreceptores seroton\u00e9rgicos en la acci\u00f3n de los f\u00e1rmacos antidepresivos. diferencias entre las v\u00edas del rafe dorsal y medial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ildefonso Hervas Roque <\/strong><\/h2>\n<p>Dada la importancia terap\u00e9utica de los inhibidores selectivos de la recaptaci\u00f3n de serotonina(isrss) en el tratamiento de la depresi\u00f3n y de otros trastornos psiqui\u00e1tricos, este trabajo ha tenido como objetivo central el estudio del mecanismo de acci\u00f3n de estos f\u00e1rmacos en el sistema neurotransmisor seroton\u00e9rgico para el desarrollo de terapias antidepresivas cada m\u00e1s r\u00e1pidas y eficaces. A grandes rasgos, y utilizando la microdi\u00e1lisis intracerebral como herramienta de trabajo principal, se han observado los efectos de tratamientos \u00fanicos y prolongados con isrs, especialmente la fluoxetina, el antidepresivo m\u00e1s prescrito en la actualidad; se ha estudiado la respuesta de los receptores seroton\u00e9rgicos que regulan la liberaci\u00f3n de serotonina (5-ht) en \u00e1reas de proyecci\u00f3n, los autoreceptores somatodendr\u00edticos 5-ht1 a y los autoreceptores terminales 5-ht1 b en presencia de estos compuestos; como consecuencia del papel limitador de estos receptores, se ha estudiado la potenciaci\u00f3n de los efectos de los antidepresivos mediante la coadministraci\u00f3n de antagonistas de los receptores 5-ht1 a y 5-ht1 b, se ha explorado la viabilidad neuroqu\u00edmica de nuevas terapias antidepresivas, que combinar\u00edan en una misma entidad molecular afinidad por el transportador de 5-ht y por el receptor 5-ht1 a. Finalmente, se ha hecho \u00e9nfasis en la caracterizaci\u00f3n de las diferentes respuestas de les v\u00edas serton\u00e9rgicas del n\u00facleo dorsal del rafe y del n\u00facleo medial del rafe, las dos fuentes de innervaci\u00f3n seroton\u00e9rgica del cerebro anterior en mam\u00edferos, proponiendo mecanismos que explicar\u00edan estas diferencias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los autorreceptores seroton\u00e9rgicos en la acci\u00f3n de los f\u00e1rmacos antidepresivos. diferencias entre las v\u00edas del rafe dorsal y medial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los autorreceptores seroton\u00e9rgicos en la acci\u00f3n de los f\u00e1rmacos antidepresivos. diferencias entre las v\u00edas del rafe dorsal y medial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ildefonso Hervas Roque <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> <\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Albert Badia Sancho <\/li>\n<li>Agustina Garc\u00eda S\u00e1nchez (vocal)<\/li>\n<li> Mico Segura Juan  Antonio (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ildefonso Hervas Roque Dada la importancia terap\u00e9utica de los inhibidores selectivos de la recaptaci\u00f3n de serotonina(isrss) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,183],"tags":[14198,46,177456,1866],"class_list":["post-83839","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","tag-agustina-garcia-sanchez","tag-albert-badia-sancho","tag-ildefonso-hervas-roque","tag-mico-segura-juan-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=83839"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/83839\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=83839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=83839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=83839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}