{"id":83857,"date":"2018-03-10T00:08:03","date_gmt":"2018-03-10T00:08:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-factor-de-necrosis-tumoral-alpha-en-la-hepatotoxicidad-inducida-por-d-galactosamina-y-en-la-proteccion-por-prostaglandina-e1\/"},"modified":"2018-03-10T00:08:03","modified_gmt":"2018-03-10T00:08:03","slug":"papel-del-factor-de-necrosis-tumoral-alpha-en-la-hepatotoxicidad-inducida-por-d-galactosamina-y-en-la-proteccion-por-prostaglandina-e1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-factor-de-necrosis-tumoral-alpha-en-la-hepatotoxicidad-inducida-por-d-galactosamina-y-en-la-proteccion-por-prostaglandina-e1\/","title":{"rendered":"Papel del factor de necrosis tumoral-alpha en la hepatotoxicidad inducida por d-galactosamina y en la proteccion por prostaglandina -e1"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lozano Reina Jos\u00e9 Manuel <\/strong><\/h2>\n<p>Introducci\u00f3n  el factor de necrosis tumoral ( tnf-) es un factor implicado en el da\u00f1o hepatocelular que participar\u00eda a su vez en la repsuesta inflamatoria desencadenada, siendo origen de la cascada de citoquinas y mediadores celulares. Los efectos biol\u00f3gicos atribuidos al tnf- son las consecuencias de la uni\u00f3n de dicho factor a sus dos receptores de membrana descritos, tnf-r55 y tnf-r75. Tnf-r55 se relaciona con los efectos citot\u00f3xicos atribuidos al tnf-,por el contrario se desconoce la acci\u00f3n del tnf-r75.  las prostaglandinas (pgs) han demostrado ser citoprotectoreas, mejorando la necrosis en una lesi\u00f3n hep\u00e1tica. Se ha especulado sobre los mecanismos de acci\u00f3n de las pgs, entre los que estar\u00eda su efecti inmunomodulador.  materia y m\u00e9todos  se provoc\u00f3 una lesi\u00f3n hep\u00e1tica por d-galactosamina (d-gain) wistar macho, dividi\u00e9ndolas en 8 grupos: control, d-gain, pge1, pge1+ d-gain, anti-tnf- +d-gain, antinecrosis y apoptosis.Se midieron los niveles intrahep\u00e1ticos de tnf- y serol\u00f3gicos de tnf, il-1, il-6, ifn y \u00f3xido n\u00edtrico (no) as\u00ed como los niveles de activaci\u00f3n de linfocitos t y de monocitos\/macr\u00f3fagos. tambi\u00e9n se evalu\u00f3 la expresi\u00f3n hep\u00e1tica de los receptores tnf-r55 y tnf-r75 para el tnf-.  conclusiones  1. El tratamiento con d-gain induce necrosis y apoptosis en el h\u00edgado.  2. Esta lesi\u00f3n hep\u00e1tica se relaciona con la activaci\u00f3n de macr\u00f3fagos \/monocitos circulantes y la liberaci\u00f3n de tnf-, il-6 e ifn. As\u00ed mismo, este da\u00f1o hepatocelular se asocia con un aumento de la expresi\u00f3n del receptor p55 para el tnf.  3. La administraci\u00f3n de anticuerpo anti-tnf reduce en un 50% la lesi\u00f3n hep\u00e1tica lo que indica la existencia de otros factores implicados en el desarrollo de la toxicidad por d-gain.  4. La pre-adminsitraci\u00f3n de pge1, reduce todos las par\u00e1metros de lesi\u00f3n hep\u00e1tica inducida por d-gain.  5. La protecci\u00f3n por pge1 revierte las alteraciones inmunes inducidas por d-gain.  6. La adminst<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del factor de necrosis tumoral-alpha en la hepatotoxicidad inducida por d-galactosamina y en la proteccion por prostaglandina -e1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del factor de necrosis tumoral-alpha en la hepatotoxicidad inducida por d-galactosamina y en la proteccion por prostaglandina -e1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lozano Reina Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gonzalo Mi\u00f1o Fugarolas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Jurado jimenez <\/li>\n<li>pl\u00e1cido Navas lloret (vocal)<\/li>\n<li>Manuel De la mata garcia (vocal)<\/li>\n<li>Jos\u00e9 Carlos Fern\u00e1ndez-checa torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lozano Reina Jos\u00e9 Manuel Introducci\u00f3n el factor de necrosis tumoral ( tnf-) es un factor implicado en 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