{"id":83858,"date":"2018-03-10T00:08:03","date_gmt":"2018-03-10T00:08:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alergenos-del-polen-de-olivoolea-europaea-ligantes-del-calcio\/"},"modified":"2018-03-10T00:08:03","modified_gmt":"2018-03-10T00:08:03","slug":"alergenos-del-polen-de-olivoolea-europaea-ligantes-del-calcio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alergenos-del-polen-de-olivoolea-europaea-ligantes-del-calcio\/","title":{"rendered":"Alergenos del polen de olivo(olea europaea) ligantes del calcio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amalia Ledesma Fern\u00e1ndez <\/strong><\/h2>\n<p>La alergia at\u00f3pica es un tipo de hipersensibilidad basada en la producci\u00f3n de anticuerpos ige contra ant\u00edgenos en principio inocuos(alergenos). El polen de gram\u00edneas, arbustos y \u00e1rboles constituye una importante fuente de alergia. Entre ello, el polen de olivo, destaca por su alta incidencia en los pa\u00edses mediterr\u00e1neos. En la presente memoria se presenta el clonaje y expresi\u00f3n en e. Coli de dos alergenos del polen de olivo(ole e 3 y ole e 8). La primera es una prote\u00edna de 9.2 kda que presenta reacci\u00f3n cruzada con prote\u00ednas hom\u00f3logas presentes en distintas fuentes alerg\u00e9nicas. Ole e 8, tiene una masa molecular de 18.7 kda y muestra una fuerte tendencia a dimerizar. Ambas prote\u00ednas contienen en su secuencia motivos estructurales de uni\u00f3n de calcio de tipo ef-hand, dos en ole e 3 y cuatro en ole e 8. este \u00faltimo alergeno sufre importantes cambios conformacionales dependientes de la uni\u00f3n a calcio, dichos cambios conformacionales dependientes de la uni\u00f3n a calcio, dichos cambios se manifestan en cambios en la movilidad electrofor\u00e9tica de la prote\u00edna, as\u00ed como cambios en los espectros de dicro\u00edsmo circular y fluorescencia. Por otra parte se ha demostrado una menor afinidad de los anticuerpos ige e igg por las formas de estos alergenos libres de calcio. As\u00ed variantes hipoalerg\u00e9nicas de estas prote\u00ednas podr\u00edan ser utilizadas en tratamientos de inmunoterapia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alergenos del polen de olivo(olea europaea) ligantes del calcio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alergenos del polen de olivo(olea europaea) ligantes del calcio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amalia Ledesma Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosalia Rodriguez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Gavilanes franco <\/li>\n<li>Manuel Lombardero vega (vocal)<\/li>\n<li>Jes\u00fas Avila de grado (vocal)<\/li>\n<li>joaqu\u00edn Quieralte enriquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amalia Ledesma Fern\u00e1ndez La alergia at\u00f3pica es un tipo de hipersensibilidad basada en la producci\u00f3n de anticuerpos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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