{"id":83968,"date":"2018-03-10T00:08:12","date_gmt":"2018-03-10T00:08:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre\/"},"modified":"2018-03-10T00:08:12","modified_gmt":"2018-03-10T00:08:12","slug":"efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre\/","title":{"rendered":"\u00abefectos de mutaciones en el locus de enzimas metabolizadoras de farmacos en el hombre\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Gallardo Vellido <\/strong><\/h2>\n<p>Las enzinas metabolizadoras de f\u00e1rmacos y carcinn\u00f3genos contienen dos tipos principales de enzimas: las de fase i, constituida principalmente por las enzimas del citocromo p450, y las de fase ii, como las n-acetiltrnasferasas entre otras. Ya que estas enzimas est\u00e1n implicadas en procesos de activaci\u00f3n y desactivaci\u00f3n de carcin\u00f3genos y mut\u00e1genos, se puede predecir que cualquier alteraci\u00f3n en la actividad de estas enzimas podr\u00eda resultar en una alterada susceptiblidad para el c\u00e1ncer. Se ha etudiado la implicaci\u00f3n de algunas de estas enzimas ( cyp2d6, cyup3a, nat1 y nat2) en el riesgo de desarrollar c\u00e1ncer de prostata. El gen codificador de las enzimas nat1 y nat2 est\u00e1 localizado en una regi\u00f3n que frecuentemente se pierde en algunos tipos de tumores, entre ellos el c\u00e1ncer de pr\u00f3stata. Mediante pcr (reacci\u00f3n en cadena de la polimerasa) y rflp (polimorfismo de longitud de fragmentos de restricci\u00f3n) se detectaron mutaciones de los genes cyp2d6 y nat2 en 94 pacientes con c\u00e1ncer de pr\u00f3stata y 160 voluntarios sanos. 11 muestras de tejido de pr\u00f3stata fueron genotipadas para cyp3a y nat2 usando los sustratos espec\u00edficos dextrometorfano, dextorfano y sulfametacina respectivamente. en general se obtuvieron las siguientes conclusiones: en tejido prost\u00e1tico humano se expresan actividades enzim\u00e1ticas dextrometorfano o-demetilasa, dextrofano n-demetilasa y sufametacina n-acetiltransferasa. Todas ellas presentaron considerable variablidad interindiviudal. La actividad dextrometorfan o-demetilasa tiene caracter\u00edsticas cin\u00e9ticas similares a la actividad cyp2d6 hep\u00e1tica humana y nmuestra dependencia con el genotipo cyp2d6. La actividad dextrorfano n-demetilasa tiene caracter\u00edsticas cin\u00e9ticas similares a la actividad cyp3a hep\u00e1tiaca humana. La actividad sulfametacina n-acetiltranserasa tiene caracter\u00edsticas cin\u00e9ticas diferentes de la actividad n-acetiltrnsfersa hep\u00e1tica no muestra dependencia con los genopitos nat1 ni nat 2, por t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abefectos de mutaciones en el locus de enzimas metabolizadoras de farmacos en el hombre\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abefectos de mutaciones en el locus de enzimas metabolizadoras de farmacos en el hombre\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Gallardo Vellido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>ag\u00fandez P\u00e9rez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Jos\u00e9 Carlos Cameselle vi\u00f1a (vocal)<\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero quesada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Gallardo Vellido Las enzinas metabolizadoras de f\u00e1rmacos y carcinn\u00f3genos contienen dos tipos principales de enzimas: las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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