{"id":83969,"date":"2018-03-10T00:08:12","date_gmt":"2018-03-10T00:08:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre-2\/"},"modified":"2018-03-10T00:08:12","modified_gmt":"2018-03-10T00:08:12","slug":"efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/efectos-de-mutaciones-en-el-locus-de-enzimas-metabolizadoras-de-farmacos-en-el-hombre-2\/","title":{"rendered":"Efectos de mutaciones en el locus de enzimas metabolizadoras de f\u00e1rmacos en el hombre"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Gallardo Vellido <\/strong><\/h2>\n<p>Las enzimas metabolizadoras de f\u00e1rmacos y carcin\u00f3genos contienen dos tipos principales de enzimas: las de fase i, constituida principalmente por las enzimas del citocromo p450, y las de fase ii, comola sn-acetiltransferasas entre otras. Ya que estas enzimas est\u00e1n implicadas en el proceso de activaci\u00f3n y desactivaci\u00f3n de carcin\u00f3genos y mut\u00e1genos, se puede predecir que cualquier alteraci\u00f3n en la actividad de estas enzimas podr\u00eda resultar en una alterada susceptibilidad para el c\u00e1ncer. Se ha estudiado la implicaci\u00f3n de algunas de estas enzimas.  cyp2d6, cyp3a, nat1 y nat2 en el riesgo de desarrollar c\u00e1ncer de prostata. el gen codificador de las enzimas nat1 y nat2 est\u00e1 localizado en una regi\u00f3n que frecuentemente se pierde en algunos tipos de tumores, entre ellos el c\u00e1ncer de pr\u00f3stata. Mediante pcr (reacci\u00f3n en cadena de la polimerasa) y rflp (polimorfismo de longitud de fragmentos de restricci\u00f3n) se detectaron mutaciones de los genes cyp2d6 y nat2 en 94 pacientes con c\u00e1ncer de pr\u00f3stata y 160 voluntarios sanos. 11 muestras de tejido de pr\u00f3stata fueron genotipadas para cyp2d6, nat1 y nat2 y determinada la actividad enzim\u00e1tica cyp2d6, cyp3a y nat2 usando los sustratos espec\u00edficos dextrometorfano, dextrofano y sulfametacina respectivamente. En general se obtuvieron las siguientes conclusiones: en el tejido prost\u00e1tico humano se expresan actividades enzim\u00e1ticas dextrometorfano o-demetilasa, dextrofano n-demetilasa y sulfametacina n-acetiltransferasa. todas ellas presentaron considerable variabilidad interindividual. La actividad dextrometorfan o-demetilasa tiene caracter\u00edsticas cin\u00e9ticas similares a la actividad cyp2d6 hep\u00e1tica humana y muestra dependencia con el genotipo cyp2d6 hep\u00e1tica humana y muestra dependencia con el genotipo cyp2d6. La actividad dextrofano n-demetilasa tiene caracter\u00edsticas cin\u00e9ticas similares a la actividad cyp3a4 hep\u00e1tica humana. La actividad sulfametacina n-acetiltransferasa tiene caracter<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de mutaciones en el locus de enzimas metabolizadoras de f\u00e1rmacos en el hombre<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de mutaciones en el locus de enzimas metabolizadoras de f\u00e1rmacos en el hombre <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Gallardo Vellido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>ag\u00fandez P\u00e9rez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Jos\u00e9 Carlos Cameselle Vi\u00f1a (vocal)<\/li>\n<li>Jos\u00e9 Enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero Quesada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Gallardo Vellido Las enzimas metabolizadoras de f\u00e1rmacos y carcin\u00f3genos contienen dos tipos principales de enzimas: las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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