{"id":840,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/investigacion-del-mecanismo-de-accion-de-la-aminoguanidina-sobre-la-glicacion-y-lipoxidacion-de-las-proteinas\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"investigacion-del-mecanismo-de-accion-de-la-aminoguanidina-sobre-la-glicacion-y-lipoxidacion-de-las-proteinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/investigacion-del-mecanismo-de-accion-de-la-aminoguanidina-sobre-la-glicacion-y-lipoxidacion-de-las-proteinas\/","title":{"rendered":"Investigacion del mecanismo de accion de la aminoguanidina sobre la glicacion y lipoxidacion de las proteinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Rodr\u00edguez Requena <\/strong><\/h2>\n<p>Las reacciones de glicacion y lipoxidacion de las proteinas estan implicadas en el desarrollo de importantes procesos fisiopatologicos, como la aterogenesis, las complicaciones de la diabetes mellitus y el envejecimiento. La aminoguanidina es un inhibidor de la glicacion avanzada de las proteinas que se ha usado con exito en la prevencion de diversas complicaciones de la diabetes mellitus en modelos animales. En este trabajo se investiga el mecanismo de accion de la aminoguanidina, aportandose pruebas de que no consiste principalmente en el bloqueo de productos de amadori ni en la inhibicion de la glicacion temprana por reaccion directa con la glucosa. Se describe la formacion de compuestos de bajo peso molecular con absorvancia caracteristica a 320 nm que podrian ser productos de reaccion de la aminoguanidina con intermediarios dicarbonilicos de la glicacion avanzada. Por otra parte, se demuestra que la aminoguanidina es capaz de inhibir la lipoxidacion de las proteinas, o reaccion de las mismas a traves de sus grupos amino con compuestos electrofilicos derivados de la lipoperoxidacion. Mas especificamente, se demuestra que la aminoguanidina inhibe la modificacion oxidativa de las lipoproteinas de baja densidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigacion del mecanismo de accion de la aminoguanidina sobre la glicacion y lipoxidacion de las proteinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion del mecanismo de accion de la aminoguanidina sobre la glicacion y lipoxidacion de las proteinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Rodr\u00edguez Requena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Cabezas Cerrato<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Bl\u00e1zquez Fern\u00e1ndez <\/li>\n<li> Paz Fernandez Juan  Manuel (vocal)<\/li>\n<li>Jos\u00e9 Enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Eugenio Uriarte Villares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Rodr\u00edguez Requena Las reacciones de glicacion y lipoxidacion de las proteinas estan implicadas en el desarrollo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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