{"id":8400,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/papel-de-la-flora-bacteriana-en-la-evolucion-de-la-enfermedad-inflamatoria-intestinal-inducida-por-el-acido-246-trinitrobencenosulfonico-en-la-rata\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"papel-de-la-flora-bacteriana-en-la-evolucion-de-la-enfermedad-inflamatoria-intestinal-inducida-por-el-acido-246-trinitrobencenosulfonico-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-flora-bacteriana-en-la-evolucion-de-la-enfermedad-inflamatoria-intestinal-inducida-por-el-acido-246-trinitrobencenosulfonico-en-la-rata\/","title":{"rendered":"Papel de la flora bacteriana en la evolucion de la enfermedad inflamatoria intestinal inducida por el acido 2,4,6-trinitrobencenosulfonico en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sebastian Videla Ces <\/strong><\/h2>\n<p>Para esclarecer el papel de la microflora intestinal en la patogenesis de la colitis cronica, se ha investigado el efecto de diferentes agentes antimicrobianos en la colitis experimental inducida por el acido 2,4,6-trinitrobencenosulfonico (tnbs). Ratas macho sprague-dawley recibieron 60 mg de tnbs en 1 ml de etanol al 10%. Cada experimento constaba de 2 grupos (n=15), control (tnbs) y antibiotico (tnbs + antibiotico).  diferentes antibioticos (imipenem\/cilastatina (i), 50 mg\/kg; vancomicina (v), 50 mg\/kg; eritromicina base (e), 40 mg\/kg; tobramicina (t), 2 mg\/kg; metronidazol (m), 20 mg\/kg); imipenem\/cilastatina + vancomicina (i+v), 50+50 mg\/kg) fueron administrados desde 3 dias antes de la instilacion del tnbs hasta 7 dias despues. En los dias 7 (fase aguda) y 21 (fase cronica) despues del tnbs se cuantifico la liberacion intraluminal de eicosanoides mediante dializado intracolonico. Posteriormente, se mataron las ratas para la evaluacion a ciegas de la lesion intestinal macroscopica e histologica, usando una escala de puntuacion de 0 a 20. En el dia 7, se realizaron coprocultivos para aerobios y anaerobios.  el tratamiento con antibioticos selectivos contra bacterias gram-positivas, gram-negativas o anaerobias no tuvo efecto sobre la lesion colonica ni sobre la liberacion de eicosanoides. En cambio, cuando se trataron con la asociacion de i+v con actividad de amplio espectro, se redujo significativamente tanto el indice de lesion macroscopico como histologico agudo (control:  17+-13,20 y i+v:9+-8,13, mediana+-percentil25, percentil75, \u00abu\u00bb de mann-whitney, p&lt;0.05) y cronico (control: 18+- 13, 20, y i+v: 5.5+- 3, 14, p&lt;0.05). En el grupo tratado con esta asociacion de antibioticos no se observaron los signos tipicos de la colitis cronica tales como estenosis, adherencias, fibrosis y granulomas. En el dia 21, la liberacion de pge2, txb2 y ltb4 en los grupos control estaba significativamente aumentada, mientras que en los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la flora bacteriana en la evolucion de la enfermedad inflamatoria intestinal inducida por el acido 2,4,6-trinitrobencenosulfonico en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la flora bacteriana en la evolucion de la enfermedad inflamatoria intestinal inducida por el acido 2,4,6-trinitrobencenosulfonico en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sebastian Videla Ces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaume Vilaseca Momplet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Malagelada Benapres Joan Ramon <\/li>\n<li>Goncal Go\u00f1alons Sintes (vocal)<\/li>\n<li> Forn Dalmau Fco. Javier (vocal)<\/li>\n<li>J. Oriol Bulbena Moreu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sebastian Videla Ces Para esclarecer el papel de la microflora intestinal en la patogenesis de la colitis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,491,139],"tags":[29516,29515,29517,29513,29514,29512],"class_list":["post-8400","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-gastroenterologia","category-medicina-interna","tag-forn-dalmau-fco-javier","tag-goncal-gonalons-sintes","tag-j-oriol-bulbena-moreu","tag-jaume-vilaseca-momplet","tag-malagelada-benapres-joan-ramon","tag-sebastian-videla-ces"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=8400"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8400\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=8400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=8400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=8400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}