{"id":84005,"date":"2018-03-10T00:08:12","date_gmt":"2018-03-10T00:08:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-serologicos-de-autoinmunidad-en-la-hepatitis-cronica-por-virus-c\/"},"modified":"2018-03-10T00:08:12","modified_gmt":"2018-03-10T00:08:12","slug":"marcadores-serologicos-de-autoinmunidad-en-la-hepatitis-cronica-por-virus-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-serologicos-de-autoinmunidad-en-la-hepatitis-cronica-por-virus-c\/","title":{"rendered":"Marcadores ser\u00f3logicos de autoinmunidad en la hepatitis cr\u00f3nica por virus c"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda   Inmaculada Alarcon  Torres <\/strong><\/h2>\n<p>La infecci\u00f3n por virus c se ha asociado a la presencia de diversas manifestaciones cl\u00ednicas extrahep\u00e1ticas. En el presente trabajo de tesis doctoral se ha estudiado, en un grupo de 255 sujetos donantes de sangre supuestamente sanos y en 395 pacientes con hcvc, la presencia de marcadores serol\u00f3gicos de autoinmunidad (autoanticuerpos) y se han relacionado con la edad, g\u00e9nero, tiempo de evoluci\u00f3n de la infecci\u00f3n, v\u00eda de transmisi\u00f3n, histolog\u00eda, genotipo del virus c, patolog\u00eda autoinmune asociada a la hcvc y con los alelos de clase ii, dr y dqb1.  el 72% de los pacientes con hcvc presentan autoanticuerpos positivos y los que se encuentran con m\u00e1s frecuencia son los ana (52%), sma (20%), ta-m (16%) y fr (26%).  en nuestros pacientes, los anticuerpos anti-lkm asociados a la hcvc, hai-2b, se encuentran en un 2% de los casos. En el an\u00e1lisis de regresi\u00f3n multivariado, el sexo femenino y la infecci\u00f3n por virus c se asocian a la presencia de autoanticuerpos, mientras que los t\u00edtulos altos de estos se asocian adem\u00e1s con la edad superior a 45 a\u00f1os. La presencia del virus c en nuestro grupo de pacientes supone un riesgo superior a presentar ana positivos y adem\u00e1s, el sexo femenino supone un riesgo superior a presentar ta-m positivos y adem\u00e1s, el sexo femenino supone un riesgo superior a presentar  ta-m positivos que en los sujetos supuestamente sanos. Los alelos dr7 y dqb1*0303, as\u00ed como el alelo dqb1*0607 se asocian a los pacientes hiperproductores de autoanticuerpos sin enfermedad autoinmune cl\u00ednicamente manifesta; el an\u00e1lisis de regresi\u00f3n demuestra que, adem\u00e1s del alelo dr7, el genotipo 1b es otro factor asociado a ellos, mientras que el alelo dqb1*0602 es un marcador genuino de aquellos pacientes con hcvc y patolog\u00eda autoinmune reum\u00e1tica asociada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores ser\u00f3logicos de autoinmunidad en la hepatitis cr\u00f3nica por virus c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores ser\u00f3logicos de autoinmunidad en la hepatitis cr\u00f3nica por virus c <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda   Inmaculada Alarcon  Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez San Roman Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: zoilo Gonz\u00e1lez lama <\/li>\n<li>Luis Inglada galiana (vocal)<\/li>\n<li>Juan Cabrera cabrera (vocal)<\/li>\n<li>Carlos Bosch millares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Inmaculada Alarcon Torres La infecci\u00f3n por virus c se ha asociado a la presencia de diversas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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