{"id":84019,"date":"2000-03-04T00:00:00","date_gmt":"2000-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/potencial-trombogenico-y-equilibrio-proliferacion-apoptosis-en-placa-aterosclerotica-humana\/"},"modified":"2000-03-04T00:00:00","modified_gmt":"2000-03-04T00:00:00","slug":"potencial-trombogenico-y-equilibrio-proliferacion-apoptosis-en-placa-aterosclerotica-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/potencial-trombogenico-y-equilibrio-proliferacion-apoptosis-en-placa-aterosclerotica-humana\/","title":{"rendered":"Potencial trombogenico y equilibrio proliferacion apoptosis en placa aterosclerotica humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Berrospe Martinez <\/strong><\/h2>\n<p>La asociaci\u00f3n de un evento tromb\u00f3tico a la lesi\u00f3n ateroscler\u00f3tica debido a su ruptura es una de las principales causas de su sintomatolog\u00eda (angina de pecho, infarto de miocardio y muerte subita). Por lo tanto el estudio de los factores que influyen tanto en la estabilidad de la placa como en su trombogenicidad es sumamente importante para la disminuci\u00f3n de la mortalidad y morbilidad causadas por la enfermedad.  el objetivo de este estudio ha sido establecer la relacion entre la presencia de los factores de coagulacion -como marcadores de la trombogenicidad de la lesion- y el equilibrio proliferacion\/apoptosis -por su influencia en la estabilidad de la lesion- en las lesiones ateroscleroticas de coronarias humanas en relacion con la composicion y el grado de severidad de la lesion.  60 coronarias humanas extraidas de 20 corazones en el momento del trasplante cardiaco se procesaron para histolog\u00eda convencional (tricromico de mason, tincion de oro), inmunohistoquimica, hibridacion \u00abin situ\u00bb de rna y tecnica tunel. Se determin\u00f3 su composici\u00f3n celular (celulas musculares lisas. Monocitos\/macrofagos, linfocitos, neutr\u00f3filos y  fibroblastos), la presencia de marcadores de apoptosis(tunel,cpp32 y p53) y de proliferacion (ki67) y la presencia de factores de coagulacion: factor tisular, protombina\/trombina y fibrinogeno; ademas de la formacion de fibrina.  a medida que aumenta el grado de severidad de la lesion, aumenta la presencia en celulas apoptoticas en correlacion significativa positiva con el contenido en lipido y celulas inflamatorias y el marcador de proliferacion, aunque la relacion proliferacion\/apoposis sufre una evolucion descendente hasta la lesi\u00f3n tipo v. En la lesi\u00f3n tipo vi(la que presenta la complicaci\u00f3n tromb\u00f3tica) puede observarse una explosion proliferativa que compensa el desequilibrio observado. Estas celulas en proliferacion se relacionan con el trombo formado sobre el nucleo graso y las zonas de neovasos, zona<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Potencial trombogenico y equilibrio proliferacion apoptosis en placa aterosclerotica humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Potencial trombogenico y equilibrio proliferacion apoptosis en placa aterosclerotica humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Berrospe Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lina Badimon Maestro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Navarro <\/li>\n<li>joan Mar\u00eda Cinca cuscullola (vocal)<\/li>\n<li>Carlos Alonso-villaverde (vocal)<\/li>\n<li>jordi Soler soler (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Berrospe Martinez La asociaci\u00f3n de un evento tromb\u00f3tico a la lesi\u00f3n ateroscler\u00f3tica debido a su ruptura [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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