{"id":84064,"date":"2000-04-04T00:00:00","date_gmt":"2000-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-nuevos-antagonistas-5-ht3-y-derivados-mixtos-5-ht1a-5-ht3\/"},"modified":"2000-04-04T00:00:00","modified_gmt":"2000-04-04T00:00:00","slug":"sintesis-de-nuevos-antagonistas-5-ht3-y-derivados-mixtos-5-ht1a-5-ht3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-nuevos-antagonistas-5-ht3-y-derivados-mixtos-5-ht1a-5-ht3\/","title":{"rendered":"\u00absintesis de nuevos antagonistas 5-ht3 y derivados mixtos 5-ht1a\/5-ht3\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tejada Cazorla Ignacio David <\/strong><\/h2>\n<p>En el presente trabajo se ha llevado a cabo la sintesis de una serie de nuevas amidas derivadas del acido 4-bencimidazolcarbox\u00edlico. Mediante experimentos de desplazamiento de radioligandos in vitro, se ha determinado su afinidad y selectividad por el receptor serotonin\u00e9rgico 5-ht3. Estudios de relaci\u00f3n estructura-actividad han puesto de manifiesto los rasgos estructurales \u00f3ptimos que modulan la afinidad y selectividad 5-ht3. Tres compuestos han sido seleccionados resultando ser potentes antagonistas selectivos de este receptor.  por otro lado, con objeto de obtener nuevas generaciones de ansiol\u00edticos y en base a la optimizaci\u00f3n previa de los rasgos estructurales \u00f3ptimos para la afinidad y selectividad 5-ht3, en este trabajo se han dise\u00f1ado y sintetizado unos nuevos derivados mixtos de bencimidazol-arilpiperazina, que incorporan en una misma mol\u00e9cula los elementos estructurales de los farmac\u00f3foros 5-ht3 y 5-ht1a. Se ha destacado un compuesto por su elevada afinidad por los receptores 5-ht3 y 5-ht1a. Se ha destacado un compuesto por su elevada afinidad por los receptores 5-ht3 y 5-ht1a y su excelente selectividad frente a los receptores a1 y d2. Debido a su interesante perfil bioqu\u00edmico, este derivado ha sido seleccionado para su caracterizaci\u00f3n neurofarmacol\u00f3gica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00absintesis de nuevos antagonistas 5-ht3 y derivados mixtos 5-ht1a\/5-ht3\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00absintesis de nuevos antagonistas 5-ht3 y derivados mixtos 5-ht1a\/5-ht3\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tejada Cazorla Ignacio David <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Nacional de educaci\u00f3n a distancia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luz Lopez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: paloma Ballesteros Garc\u00eda <\/li>\n<li>Mar\u00eda  isabel Martin fontelles (vocal)<\/li>\n<li> Ortiz garcia M\u00aa Jos\u00e9 (vocal)<\/li>\n<li>Jos\u00e9 Antonio Ramos atance (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tejada Cazorla Ignacio David En el presente trabajo se ha llevado a cabo la sintesis de una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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