{"id":84077,"date":"2000-05-04T00:00:00","date_gmt":"2000-05-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/liberacion-de-los-enantiomeros-de-salbutamol-y-ketodrofeno-a-partir-de-matrices-elaboradas-con-excipientes-quirales\/"},"modified":"2000-05-04T00:00:00","modified_gmt":"2000-05-04T00:00:00","slug":"liberacion-de-los-enantiomeros-de-salbutamol-y-ketodrofeno-a-partir-de-matrices-elaboradas-con-excipientes-quirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/liberacion-de-los-enantiomeros-de-salbutamol-y-ketodrofeno-a-partir-de-matrices-elaboradas-con-excipientes-quirales\/","title":{"rendered":"Liberacion de los enantiomeros de salbutamol y ketodrofeno a partir de matrices elaboradas con excipientes quirales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aaangeles Solinis Aspiazu <\/strong><\/h2>\n<p>Muchos de los excipientes utilizados en la industria farmaceutica son quirales, por tanto en aquellas formulaciones compuestas de un farmaco rac\u00e9mico y de excipientes quirales, es posible que al igual que sucede en el organismo, se establezcan interacciones entre cada uno de los enanti\u00f3meros y el excipiente, dando lugar a la formaci\u00f3n de diastereois\u00f3meros que pueden diferir entre otras caracteristicas, en la velocidad de liberaci\u00f3n. El estudio de la liberacion de los enanti\u00f3meros de farmacos racemicos a partir de formulaciones elaboradas con excipientes quirales tiene especial importancia en el caso de formulaciones de liberaci\u00f3n sostenida, en las que la formacion de diastereois\u00f3meros entre el farmaco y el excipiente puede dar lugar a diferencias en los porcentajes de disoluci\u00f3n y velocidad que conlleven auna diferente disposicion en el organismo.  por ello esta tesis doctoral inicialmente se ha centrado en el dise\u00f1o de formulaciones de liberaci\u00f3n sostenida elaboradas a partir de excipientes quirales de uso comun en tecnolog\u00eda farmaceutica, tales como la hpmc k100m, el carbopol  940 y el alginato s\u00f3dico y el estudio de la influencia del tipo de excipiente utilizado, del ph del comprimido y del proceso de erosion en la liberaci\u00f3n de los enanti\u00f3meros de los principios activos sulfato de salbutamol y ketoprofeno. Los tres excipientes interaccionan preferentemente con el s-salbutamol y el s-ketoprofeno, la ionizaci\u00f3n condiciona la interacci\u00f3n quiral y por tanto la diferente velocidad de liberacion de los enanti\u00f3meros del salbutamol a partir de las matrices elaboradas conalginato y carbopol 940 y por \u00faltimo, cuando la liberaci\u00f3n a partir de las matrices se realiza mediante transporte an\u00f3malo, al eliminar el proceso de erosi\u00f3n del mecanismo global de liberaci\u00f3n, se favorece la liberaci\u00f3n enantioselectiva del f\u00e1rmaco.  en este trabajo tambi\u00e9n se han buscado y sintetizado nuevos excipientes quirales derivados de la celulo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Liberacion de los enantiomeros de salbutamol y ketodrofeno a partir de matrices elaboradas con excipientes quirales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Liberacion de los enantiomeros de salbutamol y ketodrofeno a partir de matrices elaboradas con excipientes quirales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aaangeles Solinis Aspiazu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Mart\u00ednez pacheco <\/li>\n<li>Juan  Jos\u00e9 Torrado duran (vocal)<\/li>\n<li>julio San roman del barrio (vocal)<\/li>\n<li>ricard Mis vizcaino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aaangeles Solinis Aspiazu Muchos de los excipientes utilizados en la industria farmaceutica son quirales, por tanto en 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