{"id":84084,"date":"2000-06-04T00:00:00","date_gmt":"2000-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/afeccion-hepatica-en-la-artritis-reumatoide-y-hepatotoxicidad-del-metotrexate-estudio-mediante-microscopia-electronica\/"},"modified":"2000-06-04T00:00:00","modified_gmt":"2000-06-04T00:00:00","slug":"afeccion-hepatica-en-la-artritis-reumatoide-y-hepatotoxicidad-del-metotrexate-estudio-mediante-microscopia-electronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/afeccion-hepatica-en-la-artritis-reumatoide-y-hepatotoxicidad-del-metotrexate-estudio-mediante-microscopia-electronica\/","title":{"rendered":"Afecci\u00f3n hep\u00e1tica en la artritis reumatoide y hepatotoxicidad del metotrexate. estudio mediante microscopia electr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Ros Exp\u00f3sito <\/strong><\/h2>\n<p>Objetivo  estudiar las alteraciones hep\u00e1ticas mediante microscopias \u00f3ptica (mo) y electr\u00f3nica (me) en los pacientes afectos de artritis reumatoide (ar) y valorar los cambios histol\u00f3gicos producidos a los 4 a\u00f1os de tratamiento con metotrexate (mtx). Determinar si la me ofrece ventajas sobre la mo en el estudio histol\u00f3gico.  pacientes y m\u00e9todos  se incluyeron 42 pacientes afectos de ar, tributarios de seguir tratamiento con mtx. Se les realiz\u00f3 una bh antes del inicio del mismo y a los 4 a\u00f1os de su instauraci\u00f3n. Recibieron dosis entre 7,5-15 mg\/sem de mtx. Se evaluaron variables cl\u00ednicas, biol\u00f3gicas, terap\u00e9uticas e histol\u00f3gicas en ambos grupos. el estudio histol\u00f3gico se realiz\u00f3 mediante mo y me.  resultados  el 14% de los pacientes presentaban fibrosis perisinusoidal leve (roenigk lla) y el resto un estadio de roenigk inferior, en la me, el 50% presentaron un aumento de fibras de col\u00e1geno en los espacios disse de sus primeras bh. En ning\u00fan paciente se observ\u00f3 un empeoramiento de los hallazgos histol\u00f3gicos en las segundas bh. Las variables que se correlacionaron con una peor histolog\u00eda fueron la edad del paciente, el tiempo de evoluci\u00f3n de la enfermedad, la ingesta de alcohol y algunos datos bioqu\u00edmicos (ggt y alb\u00famina); la dosis acumulada de mtx no se correlacion\u00f3 con la existencia de una peor histolog\u00eda. existe una buena correlaci\u00f3n entre ambas t\u00e9cnicas de microscopia, si bien la me ha demostrado mayor sensibilidad en la detecci\u00f3n de fibrosis.  conclusiones  los pacientes afectos de ar presentan afecci\u00f3n hep\u00e1tica antes del inicio del tratamiento con mtx. Esta afecci\u00f3n es leve y posiblemente multifactorial. el mtx, a dosis bajas, se muestra como un f\u00e1rmaco seguro. Adem\u00e1s de las recomendaciones de la american college of rheumatology, la edad del paciente y el tiempo de evoluci\u00f3n de la ar son factores de riesgo de afecci\u00f3n hep\u00e1tica y por lo tanto de toxicidad por mtx. La me constituye una t\u00e9cnica m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Afecci\u00f3n hep\u00e1tica en la artritis reumatoide y hepatotoxicidad del metotrexate. estudio mediante microscopia electr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Afecci\u00f3n hep\u00e1tica en la artritis reumatoide y hepatotoxicidad del metotrexate. estudio mediante microscopia electr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Ros Exp\u00f3sito <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel Roig Escofet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>josep Mu\u00f1oz gomez (vocal)<\/li>\n<li>isidro Ferrer abizanda (vocal)<\/li>\n<li>ricardo Sol\u00ed\u00a0 lamoglia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Ros Exp\u00f3sito Objetivo estudiar las alteraciones hep\u00e1ticas mediante microscopias \u00f3ptica (mo) y electr\u00f3nica (me) en los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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