{"id":84085,"date":"2000-06-04T00:00:00","date_gmt":"2000-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pesticidas-organoclorados-en-mujeres-afectadas-de-cancer-de-mama-evaluacion-del-efecto-estrogenico\/"},"modified":"2000-06-04T00:00:00","modified_gmt":"2000-06-04T00:00:00","slug":"pesticidas-organoclorados-en-mujeres-afectadas-de-cancer-de-mama-evaluacion-del-efecto-estrogenico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/pesticidas-organoclorados-en-mujeres-afectadas-de-cancer-de-mama-evaluacion-del-efecto-estrogenico\/","title":{"rendered":"Pesticidas organoclorados en mujeres afectadas de cancer de mama; evaluacion del efecto estrogenico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Botella Orts <\/strong><\/h2>\n<p>La memoria de tesis doctoral se encuadra dentro de un proyecto fis 95\/1959 en el que se estan estudiando la potencial relaci\u00f3n entre cancer de mama y exposici\u00f3n a pesticidad organoclorados (po) con efecto estrogenico.  los objetivos planteados son:  &#8211; optimizar metodolog\u00eda anal\u00edtica para extracci\u00f3n de p.O. De tejido adiposo y suero humano. Extracto susceptible de ser ensayado en test biol\u00f3gicos de estrogenicidad.  &#8211; determinaci\u00f3n de p.O. Conefecto estrog\u00e9nico mediante gd\/dce.  &#8211; estimar la idoneidad del tejido adiposo o del suero para establecer la carga estrog\u00e9nica de un individuo.  &#8211; cuantificar la actividad hormonal de los extractos del tejido adiposo y establecer la carga hormonal debida a xenobi\u00f3ticos estrog\u00e9nicos.  de desarrolla una metodolog\u00eda adecuada para el an\u00e1lisis de pesticidas organoclorados en muestras biol\u00f3gicas. El m\u00e9todo cromatrogr\u00e1fico permite la cuantificaci\u00f3n de los pesticidas organoclorados en las muestras, tanto de tejido adiposo como de suero. El contenido medio de pesticidas determinados en tejido adiposo es superior al de suero en todos los casos excepto para el endosulf\u00e1n-\u00e9ter, que presenta mayor concentraci\u00f3n media en suero.  el valor medio del cociente grasa\/suero confirma la alta afinidad de los p.O. Por el tejido adiposo. Estos datos concuerdan conlos recogidos en la lieteratura cient\u00edfica. A la vista de estos resultados, el tejido adiposo ser\u00e1 el de elecci\u00f3n para determinar la carga estrog\u00e9ncia en el proyecto en realizaci\u00f3n, al permitir un mayor rango de respuesta en el test biol\u00f3gico, y al ser un indicador de exposici\u00f3n cronica o antigua a estos pesticidas. Estos resultados muestran alta exposici\u00f3n de la poblaci\u00f3n en estudio a xenobi\u00f3ticos con acci\u00f3n hormonal.  por \u00faltimo, las conclusiones que se deducen del trabajo son:  1- que se dispone de una metodolog\u00eda \u00fatil para extraer xenoestr\u00f3genos deltejido adiposo y separarlos de estr\u00f3genos end\u00f3genos.  2- la positiv<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Pesticidas organoclorados en mujeres afectadas de cancer de mama; evaluacion del efecto estrogenico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Pesticidas organoclorados en mujeres afectadas de cancer de mama; evaluacion del efecto estrogenico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Botella Orts <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Rosario Fatima Olea Serrano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  del carmen Lopez Martinez <\/li>\n<li>bonifacio nicol\u00e1s Diaz chico (vocal)<\/li>\n<li>Manuel Repetto jimenez (vocal)<\/li>\n<li>Antonio Pla Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Botella Orts La memoria de tesis doctoral se encuadra dentro de un proyecto fis 95\/1959 en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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