{"id":84087,"date":"2000-06-04T00:00:00","date_gmt":"2000-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-funcional-de-la-p-glicoproteina-mediante-tecnicas-de-imagen-en-el-cancer-de-pulmon\/"},"modified":"2000-06-04T00:00:00","modified_gmt":"2000-06-04T00:00:00","slug":"estudio-funcional-de-la-p-glicoproteina-mediante-tecnicas-de-imagen-en-el-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-funcional-de-la-p-glicoproteina-mediante-tecnicas-de-imagen-en-el-cancer-de-pulmon\/","title":{"rendered":"Estudio funcional de la p-glicoproteina mediante tecnicas de imagen en el cancer de pulmon."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tabuenca Mateo M. Jose <\/strong><\/h2>\n<p>La glicoprote\u00edna p, tambi\u00e9n denominada p170, mdr o pgp es una prote\u00edna de membrana cuya funci\u00f3n es extraer sustancias del interior celular y expulsarlas al exterior mediante un transpsorte activo. Dichas sustancias puden ser f\u00e1rmacos sin ninguna similitud qu\u00edmica o estructural y presentan como \u00fanica caracter\u00edstica com\u00fan el comportarse como cationes lipof\u00edlicos en medios fisiol\u00f3gicos. Como consecuencia, las c\u00e9lulas cancerosas que presentan la pgp en su membrana, desarrollan resitencia a diferentes quimoterp\u00e1picos de origen natural (antracilinas, alcaloides de la vinca y podofilotoxinas).  en el presnete trabajo se ha investigago la distribuci\u00f3n y captaci\u00f3n de un cati\u00f3n lipof\u00edlico marcado con un is\u00f3topo radiactivo el tetrofosm\u00edn-99mtc (tf), en 115 pacientes conmasas pulmonares sospechosas de malginidad. Dicha captaci\u00f3n se cuantifi\u00f3 crando \u00e1reas de inter\u00e9s sobre cortes tomogr\u00e1ficos obtenidos a trav\u00e9s de la t\u00e9cnica spect. Tambi\u00e9n se ha determinado la existencia de la pgp en pacientes con c\u00e1ncer de pulm\u00f3n. Para ello se ha cuantificado la presencia de pgp en muestras de tumores mediante dos t\u00e9cnicas reconocidas: citrometr\u00eda de fllujo e inmunohistoqu\u00edmica. Los hallazgos se han comparado con los \u00edndices de captaci\u00f3n del tf.  de los resultados obtendios se puede concluir que las lesiones benignas no presentan captaci\u00f3n de tf, con un valor predictivo positivo del 97,7%. entre los factores dependientes del tumor \u00fanicamente el tama\u00f1o tumoral parece influir en la captaci\u00f3n. En los pacientes con c\u00e1ncer de pulm\u00f3n de c\u00e9lula no peque\u00f1a se ha observado una relaci\u00f3n positiva entre los \u00edndices de captaci\u00f3n tanto con la supervivencia como con la respuesta a la quimoterapia. se ha comprobado una relaci\u00f3n inversa entre la captaci\u00f3n de tf y la densidad de expresi\u00f3n de pgp determinada tanto por citometr\u00eda de flujo como por inmunohistoqu\u00edmica. En resumen, la gammagraf\u00eda contf permite la detecci\u00f3n de la pgp de fo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio funcional de la p-glicoproteina mediante tecnicas de imagen en el cancer de pulmon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio funcional de la p-glicoproteina mediante tecnicas de imagen en el cancer de pulmon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tabuenca Mateo M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Ortiz Berrocal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo D\u00edaz-rubio Garc\u00eda <\/li>\n<li> Varela de mora soto melchor (vocal)<\/li>\n<li> Carretas delgado Jos\u00e9 Luis (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tabuenca Mateo M. Jose La glicoprote\u00edna p, tambi\u00e9n denominada p170, mdr o pgp es una prote\u00edna de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,346,69,139],"tags":[177830,20991,105306,177828,177829],"class_list":["post-84087","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-diagnostico-por-imagen","category-enfermedades-pulmonares","category-medicina-interna","tag-carretas-delgado-jose-luis","tag-eduardo-diaz-rubio-garcia","tag-jose-ortiz-berrocal","tag-tabuenca-mateo-m-jose","tag-varela-de-mora-soto-melchor"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84087"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84087\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}