{"id":84104,"date":"2000-07-04T00:00:00","date_gmt":"2000-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-nuevas-series-de-diterpenoides-sintesis-del-narkamurol-a\/"},"modified":"2000-07-04T00:00:00","modified_gmt":"2000-07-04T00:00:00","slug":"estudios-de-nuevas-series-de-diterpenoides-sintesis-del-narkamurol-a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-de-nuevas-series-de-diterpenoides-sintesis-del-narkamurol-a\/","title":{"rendered":"Estudios de nuevas series de diterpenoides: sintesis del narkamurol-a"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Cuesta Perez <\/strong><\/h2>\n<p>Se describe la primera sintesis estereoselectiva de la (4as, 5r)-4a,5-dimetil-4,4a,5,6,7,8-hexahidro-3h-naftalen-2-ona. la sintesis parte de la (r)-3-metilciclohexanona, consta de 8 etapas y permite ser realizada a gran escala con un rendimiento global del 24%.  se decriben los primeros estudios realizados para alcanzar una sintesis para el producto natural nominina. En este ambito se ha alcanzado la funcionalizacion de dos centros de la naftalenona, obteniendo asi un producto con cuatro de los cinco centros asimetricos presentes en el producto natural.  se describe la primera sintesis del diterpeno de origeno marino nakamurol-a mediante una secuencia de sintesis de 16 etapas desde (r)-3-metilciclo-hexanona con un rendimiento global del orden del 25. Las etapas claves del proceso son: (i) la sintesis enantioselectiva de la naftalenona indicada anteriormente, (ii) la adicion conjugada estereoselectiva del dimetilzinc a esta enona y atrapado con formaldehido del enolato formado para generar el cetol correspondiente (iii) una reacci\u00f3n de sakurai para elongar la cadena lateral y (iv) una reaccion de wacker quimioselectiva sobre una 1,5-dicetona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de nuevas series de diterpenoides: sintesis del narkamurol-a<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de nuevas series de diterpenoides: sintesis del narkamurol-a <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Cuesta Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Bonjoch Sese<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Bosch cartes <\/li>\n<li>Jos\u00e9 Fuentes mota (vocal)<\/li>\n<li>josep Coll toledano (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Cuesta Perez Se describe la primera sintesis estereoselectiva de la (4as, 5r)-4a,5-dimetil-4,4a,5,6,7,8-hexahidro-3h-naftalen-2-ona. la sintesis parte [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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