{"id":84224,"date":"2000-12-04T00:00:00","date_gmt":"2000-12-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-a-corto-plazo-de-un-agonista-adrenergico-beta-3-con-otros-agentes-termorregulares-efectos-sobre-la-termogenesis-y-la-expresion-de-genes-implicados-en-el-metabolismo-energetico\/"},"modified":"2000-12-04T00:00:00","modified_gmt":"2000-12-04T00:00:00","slug":"interacciones-a-corto-plazo-de-un-agonista-adrenergico-beta-3-con-otros-agentes-termorregulares-efectos-sobre-la-termogenesis-y-la-expresion-de-genes-implicados-en-el-metabolismo-energetico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interacciones-a-corto-plazo-de-un-agonista-adrenergico-beta-3-con-otros-agentes-termorregulares-efectos-sobre-la-termogenesis-y-la-expresion-de-genes-implicados-en-el-metabolismo-energetico\/","title":{"rendered":"Interacciones a corto plazo de un agonista adrenergico beta 3 con otros agentes termorregulares: efectos sobre la termogenesis y la expresion de genes implicados en el metabolismo energetico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier G\u00f3mez Ambrosi <\/strong><\/h2>\n<p>La obesidad constituye una de las alteraciones metab\u00f3licas m\u00e1s frencuentes en el mundo occidental y en los paisaes en vias de desarrollo. Este hecho justifica el continuo inter\u00e9s de la comunidad cientifica por conocer los mecanismos fisiol\u00f3gicos que controlan la homeostasis energ\u00e9tica. En este sentido, se ha sugerido que la leptina y el sistema nervioso autonomo podr\u00edan desempe\u00f1ar un papel fundamental en la regulaci\u00f3n del metabolismo energetico. en el presente estudio se han evaluado los efectos de un agonista adren\u00e9rgico b3(trecadrine), la leptina,un antagonista adrenergico a2(yohimbina) y un antagonista muscar\u00ednico m1 (pirenzepina) en ratas wistar y la posible interacci\u00f3n de cada uno de los tres ultimos con el trecadrine, en la termog\u00e9nesis y la lipolisis. Los resultados obtenidos demuestran que la leptina, la yohimbina y la pirenzepina presentan efecto lipol\u00edtico in vitro sobre el tejido adiposo blanco y potencian el efecto lipol\u00edtico del trecadrine. La leptina produce efecto termog\u00e9nico a trav\u00e9s de aumentos en la expresi\u00f3n de ucp3 en musculo. la yohimbina presentan un efecto dual, aumentando la lipolisis pero disminuyendo la temperatura corporal, probablemente por sus efectos centrales. El trecadrine produjo un marcado efecto termog\u00e9nico debido a la inducci\u00f3n de la ucp1 en bat y en el cual tambien podria estar implicado el aumento observado en la expresi\u00f3n de pgc-1. El marcado efecto lipolitico in vivo del trecadrine parece deberse a una acci\u00f3n sobre el tejido adiposo pardo m\u00e1s que sobre el tejido adiposo blanco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones a corto plazo de un agonista adrenergico beta 3 con otros agentes termorregulares: efectos sobre la termogenesis y la expresion de genes implicados en el metabolismo energetico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones a corto plazo de un agonista adrenergico beta 3 con otros agentes termorregulares: efectos sobre la termogenesis y la expresion de genes implicados en el metabolismo energetico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier G\u00f3mez Ambrosi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alfredo Martinez Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  pilar Fernandez otero <\/li>\n<li>gregorio Varela moreiras (vocal)<\/li>\n<li>edurne Cenarruzabeitia sagarminaga (vocal)<\/li>\n<li>francisca Perez llamas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier G\u00f3mez Ambrosi La obesidad constituye una de las alteraciones metab\u00f3licas m\u00e1s frencuentes en el mundo occidental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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