{"id":84240,"date":"2018-03-10T00:08:29","date_gmt":"2018-03-10T00:08:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/autoasociacion-de-la-proteina-p6-del-bacteriofago-029-de-bacillus-subtilis\/"},"modified":"2018-03-10T00:08:29","modified_gmt":"2018-03-10T00:08:29","slug":"autoasociacion-de-la-proteina-p6-del-bacteriofago-029-de-bacillus-subtilis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/autoasociacion-de-la-proteina-p6-del-bacteriofago-029-de-bacillus-subtilis\/","title":{"rendered":"Autoasociacion de la proteina p6 del bacteriofago 029 de bacillus subtilis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M. Abril Gallego <\/strong><\/h2>\n<p>En este trabajo se ha estudiado la autoasociaci\u00f3n de la proteina p6 del bateri\u00f3fago 029 de bacillus subtilis desde dos puntos de vista, estructural y funcional. A nivel estructural hemos descrito que la proteina p6 en solucion y en el intervalo de concentracion entre 1 y 100 um, se encuentra en un equilibrio monomero-dimero con una constante de dimerizaci\u00f3n de 2,0&#215;10 5 m-1. Sin embargo, a concentraciones cercanas a las encontradas in vivo(1 mm), los d\u00edmeros pueden autoasociar para formar oligomeros, con una constante de uni\u00f3n de 0,95 x 10 3 m-1. A menor temperatura y a mayor fuerza i\u00f3nica la prote\u00edna p6 autoasocia mejor, lo que indica que las fuerzas predominantes que intervienen en la autoasociaci\u00f3n son, probablemente,puentes de hidrogeno y\/o fuerzas de van der waals.  los olig\u00f3meros que forma la prote\u00edna p6 se observan al microscopio electr\u00f3nico de transmisi\u00f3n de forma alargada y curva, y sus medidas son comparables a las del dna en el complejo previamente descrito. Se sugiere que estos agregados sean la unidad minima de estabilizaci\u00f3n del complejo proteina p6-dna, y que esten formados por 7 u 8 dimeros de proteina. En ausencia de dna, la proteina p6 puede formar filamentos a derechos, probablemente mediante un proceso de nucleaci\u00f3n a partir de los agregados alargados y curvos.  desde el punto de vista estructural hemos descrito regiones de la proteina implicadas tanto positiva como negativamente en la dimerizaci\u00f3n. El extremo carboxilo terminal de la proteina dificulta la autoasociaci\u00f3n de la prote\u00edna p6 in vitro, por lo que se ha propuesto como modulador de este mecanismo. la proteina p6 autoasocia in vivo; parecen existir dos regiones implicadas, el extremo amino y una region central. La caracterizaci\u00f3n de mutantes puntales en cada una de las regiones implicadas en la autoasociaci\u00f3n de la proteina p6 in vivo,ha permitido determinar que la isoleucina en posici\u00f3n 8 es critica para la dimerizaci\u00f3n de la proteina p6<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Autoasociacion de la proteina p6 del bacteriofago 029 de bacillus subtilis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Autoasociacion de la proteina p6 del bacteriofago 029 de bacillus subtilis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M. Abril Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Miguel Hermoso  Nu\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Espinosa padr\u00f3n <\/li>\n<li>Jos\u00e9 Mar\u00eda Almendral del rio (vocal)<\/li>\n<li>Jos\u00e9 Lopez carrascosa (vocal)<\/li>\n<li>german Rivas caballero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M. Abril Gallego En este trabajo se ha estudiado la autoasociaci\u00f3n de la proteina p6 del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[279,36483,36606,35,280],"tags":[178062,51885,21426,15326,14480,10986],"class_list":["post-84240","post","type-post","status-publish","format-standard","hentry","category-bacteriofagos","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-ciencias-de-la-vida","category-virologia","tag-ana-m-abril-gallego","tag-german-rivas-caballero","tag-jose-lopez-carrascosa","tag-jose-maria-almendral-del-rio","tag-jose-miguel-hermoso-nunez","tag-manuel-espinosa-padron"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84240"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84240\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}