{"id":84282,"date":"2018-03-10T00:08:34","date_gmt":"2018-03-10T00:08:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribucion-de-los-genes-erma-ermb-y-mefa-en-streptococcus-pneumoniae-y-pyogenes-y-su-relacion-con-los-transposones-conjugativos\/"},"modified":"2018-03-10T00:08:34","modified_gmt":"2018-03-10T00:08:34","slug":"distribucion-de-los-genes-erma-ermb-y-mefa-en-streptococcus-pneumoniae-y-pyogenes-y-su-relacion-con-los-transposones-conjugativos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/distribucion-de-los-genes-erma-ermb-y-mefa-en-streptococcus-pneumoniae-y-pyogenes-y-su-relacion-con-los-transposones-conjugativos\/","title":{"rendered":"Distribuci\u00f3n de los genes erm(a), erm(b) y mef(a) en streptococcus pneumoniae y pyogenes y su relaci\u00f3n con los transposones conjugativos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Seral Garcia <\/strong><\/h2>\n<p>El aislamiento cl\u00ednico del g\u00e9nero streptococcus hemos comprobado el incremento de la resistencia adquirida a macr\u00f3lidos, de alto y bajo nivel, con fenotipo mlsb constitutivo en neumococos y estreptococos de los grupos c y g, y fenotipo m en s.Pyogenes. En las cepas de s. Pneumoniae y s.Pyogenes con fenotipo cmlsb, el gen erm(b) es el que codifica para la metiltransferasa, en tanto que en los aislamientos de estreptococos grupos c y g, el m\u00e1s frecuente es el gen erm(a). El gen mef(a), determinante de resistencia por eflujo, es el responsable fundamental del fenotipo m en el g\u00e9nero streptococcus. el gen mef(a), adem\u00e1s de estar presente en s.Pneumoniae y s.Pyogenes, lo hemos encontrado en estreptococos del grupo viridans (s.Mitis), estreptococos beta-hemol\u00edticos del grupo b (s.Agalactiae) y enterococos (e.Faecalis) lo que indica una distribuci\u00f3n de este gen mucho m\u00e1s amplia de los que se hab\u00eda imaginado inicialmente. Hemos demostrado la coexistencia de varios genes de resistencia a macr\u00f3licos en cepas de neumococos y estreptococos grupos c y g son fenotipos cmlsb. En s.Pneumoniae encontramos 10 asociaciones diferentes de determinantes de resistencia, predominando: erm(b), tet(m), catpc194 y erm(b), tet(m). Era muy frecuente la asociaci\u00f3n de los genes erm(b) y tet(m) entre las cepas de los sg\/sts 15 y 6a. En contraste, la mayor\u00eda de las cepas de s.Pyogenes pose\u00edan el gen de resistencia mef(a) y no llevaban ning\u00fan determinante de resistencia asociado.  en las cepas que poseen el gen erm(b) suele estar presente el gen inttn, confirmando que el vector es el transpos\u00f3n conjugativo tn1545. Las cepas que conten\u00edan  el gen mef(a), no ten\u00edan pl\u00e1smidos ni transposones conjugativos de la familia tn1545-tn916. Este gen se asocia con elementos conjugativos localizados en el cromosoma.  el gen erm(a), encontrado en estreptococos beta-hemol\u00edticos de los grupos a. C y g se encontraba en la mayor\u00eda de las cepas sin ning\u00fan otro determina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribuci\u00f3n de los genes erm(a), erm(b) y mef(a) en streptococcus pneumoniae y pyogenes y su relaci\u00f3n con los transposones conjugativos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribuci\u00f3n de los genes erm(a), erm(b) y mef(a) en streptococcus pneumoniae y pyogenes y su relaci\u00f3n con los transposones conjugativos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Seral Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/04\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>luz Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Rubio-calvo m. <\/li>\n<li>carmen Torres (vocal)<\/li>\n<li>Jos\u00e9 Prieto (vocal)<\/li>\n<li>asunci\u00f3n Fenoll (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Seral Garcia El aislamiento cl\u00ednico del g\u00e9nero streptococcus hemos comprobado el incremento de la resistencia adquirida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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