{"id":8436,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/sepsis-por-gram-negativos-estudio-experimental-de-la-actividad-terapeutica-del-peptido-cap18106-137-en-un-modelo-porcino-de-endotoxemia\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"sepsis-por-gram-negativos-estudio-experimental-de-la-actividad-terapeutica-del-peptido-cap18106-137-en-un-modelo-porcino-de-endotoxemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sepsis-por-gram-negativos-estudio-experimental-de-la-actividad-terapeutica-del-peptido-cap18106-137-en-un-modelo-porcino-de-endotoxemia\/","title":{"rendered":"Sepsis por gram-negativos: estudio experimental de la actividad terapeutica del peptido cap18106-137 en un modelo porcino de endotoxemia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Bouza Alvarez <\/strong><\/h2>\n<p>La cap \u00abcationic antimicrobial protein\u00bb es una proteina de 18 kd, derivada de los neutrofilos que se ha comprobado se une a multiples tipos de endotoxina y los neutraliza. En estudios in vitro se ha demostrado que el fragmento c-terminal de 32 aminoacidos cap18 106-137 es aun mas efectivo que la proteina nativa para neutralizar endotoxina. Los efectos in vivo de este peptido son todavia desconocidos.  para evaluar estos efectos in vivo se ha realizado un estudio experimental sobre un modelo porcino de endotoxemia aguda intentando conocer su capacidad de impedir o reducir las alteraciones hemodinamicas y el grado de lesion pulmonar aguda secundarios a administracion de lps; asi como su capacidad de neutralizar los efectos del lps sobre el sistema fagocitico y la sintesis de mediadores sistemicos.  los animales se dividieron aleatoriamente en tres grupos.  los del grupo lps (n=7) recibieron una infusion continua de lps de e. Coli (serotipo 0111:b4) en dosis de 3 g\/kg\/h durante 4 horas. Los del grupo lps\/cap18 (n=7) recibieron la misma dosis de lps y ademas 4 mg\/kg\/h de cap18106-137 durante el mismo tiempo. Los del grupo control, rl, (n=4) no recibieron lps ni cap18.  todos los animales se sometieron a ventilacion mecanica y se hicieron determinaciones secuenciales cada 30 minutos hasta completar 4 horas de los parametros hemodinamicos y de funcion pulmonar mas utilizados en la clinica humana.  asimismo se estudiaron la cifra de leucocitos circulantes, las concentraciones plasmaticas de tnf ,6-ceto-pgf1 y txa2 y, como medida de la actividad fagocitica in vivo, la relacion core-more.  los resultados obtenidos demuestran que el peptido sintetico cap18106-137 ejerce in vivo un notable efecto protector frente a muchos de los efectos deletereos de endotoxina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sepsis por gram-negativos: estudio experimental de la actividad terapeutica del peptido cap18106-137 en un modelo porcino de endotoxemia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sepsis por gram-negativos: estudio experimental de la actividad terapeutica del peptido cap18106-137 en un modelo porcino de endotoxemia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Bouza Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 V\u00e1zquez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  Sancho Martin <\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez Montes (vocal)<\/li>\n<li> Guerrero Sanz Jos\u00e9 Eugenio (vocal)<\/li>\n<li>Jorge Garcia Seoane (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Bouza Alvarez La cap \u00abcationic antimicrobial protein\u00bb es una proteina de 18 kd, derivada de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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