{"id":84365,"date":"2000-04-05T00:00:00","date_gmt":"2000-04-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-de-rescate-en-las-leucemias-agudas-del-adulto-en-recaa%c2%adda-o-refractarias-a-quimioterapia-de-primera-linea\/"},"modified":"2000-04-05T00:00:00","modified_gmt":"2000-04-05T00:00:00","slug":"tratamiento-de-rescate-en-las-leucemias-agudas-del-adulto-en-recaa%c2%adda-o-refractarias-a-quimioterapia-de-primera-linea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-de-rescate-en-las-leucemias-agudas-del-adulto-en-recaa%c2%adda-o-refractarias-a-quimioterapia-de-primera-linea\/","title":{"rendered":"Tratamiento de rescate en las leucemias agudas del adulto en reca\u00edda o refractarias a quimioterapia de primera linea"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rodrigo Martino Bofarull <\/strong><\/h2>\n<p>Veinte adultos afectos de leucemia aguda mielobl\u00e1stica primariamente refractaria o en reca\u00edda recibieron una quimioterapia de rescate secuencial en el tiempo mediante el esquemo gemia, que contiene mitoxantrone 12 mg\/m2 dias 1-3, ara-c 500 mg\/m2 por infusi\u00f3n iv. Continua de 24 horas d\u00edas 1-3, seguido de ara-c2 g\/m2 cada 12 horas dias 6-8 y etop\u00f3sido 100 mg\/m2 cada 12 horas d\u00edas 6-8. La tasa de remisi\u00f3n completa fue de 14\/20 (70%,ic 95% 44-88%), y hubo cinco muertes por toxicidad. Con el objetivo de evaluar si el esquema gemia es superior al protocolo de rescate convencional empleado con anterioridad (relam88) en 25 pacientes, se han comparado los resultados del tratamiento con ambos protocolos. El relam88 inclu\u00eda ara-c a dosis intermedias, mitoxantrone, ciclofosfamida, prednisona y metotrexate a dosis intermedias. La tasa de remisi\u00f3n completa global obtenida con ambos protocolos no difiri\u00f3 significativamente (70% gemia vs 56% relam88). Sin embargo, dada la mayor proporci\u00f3n de pacientes refractarios tratados con gemia (85% vs 44%, respectivamente), los resultado sugieren que este esquema es mas eficaz que relam88 inclu\u00eda ara-c a dosis intermedias, mitoxantrone, ciclofosfamida, prednisona y metotrexate a dosis intermedias. La tasa de remisi\u00f3n completa global obtenida con ambos protocolos no difiri\u00f3 significativamente (70% gemia vs 56% relam88). Sin embargo, dada la mayor proporci\u00f3n de pacientes refractarios tratados con gemia(85% vs 44%, respectivamente), los resultados sugieren que este esquema es mas eficaz que relam88). Sin embargo, dada la mayor proporci\u00f3n de pacientes refractarios tratados con gemia(85% vs 44% respectivamente), los resultados sugieren que este esquema es mas eficaz que relam88 en obtener la remisi\u00f3n completa. Cincuenta y dos pacientes adultos afectos de leucemia aguda linfobl\u00e1stica refractaria o en primera reca\u00edda fueron tratados por el esquema relal, con una mediana de edad de 34 a\u00f1os(intervalo 16-62)<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento de rescate en las leucemias agudas del adulto en reca\u00edda o refractarias a quimioterapia de primera linea<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento de rescate en las leucemias agudas del adulto en reca\u00edda o refractarias a quimioterapia de primera linea <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rodrigo Martino Bofarull <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salut Brunet Mauri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Montserrat costa <\/li>\n<li>Miguel \u00e1ngel Sanz alonso (vocal)<\/li>\n<li>jordi Sierra gil (vocal)<\/li>\n<li>enric Carreras pons (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodrigo Martino Bofarull Veinte adultos afectos de leucemia aguda mielobl\u00e1stica primariamente refractaria o en reca\u00edda recibieron una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,218,195,139,1027,347,156],"tags":[19797,51559,14220,9706,153577,48617],"class_list":["post-84365","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-hematologia","category-hemopatologia","category-medicina-interna","category-oncologia","category-oncologia-clinica","category-patologia","tag-emilio-montserrat-costa","tag-enric-carreras-pons","tag-jordi-sierra-gil","tag-miguel-angel-sanz-alonso","tag-rodrigo-martino-bofarull","tag-salut-brunet-mauri"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84365"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84365\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}