{"id":84430,"date":"2000-09-05T00:00:00","date_gmt":"2000-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-enzimas-microsomales-hepaticas-y-proliferacion-peroxisomal-por-ciflutrina\/"},"modified":"2000-09-05T00:00:00","modified_gmt":"2000-09-05T00:00:00","slug":"induccion-de-enzimas-microsomales-hepaticas-y-proliferacion-peroxisomal-por-ciflutrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/induccion-de-enzimas-microsomales-hepaticas-y-proliferacion-peroxisomal-por-ciflutrina\/","title":{"rendered":"Induccion de enzimas microsomales hepaticas y proliferacion peroxisomal por ciflutrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Fern\u00e1ndez S\u00e1nchez <\/strong><\/h2>\n<p>La ciflutrina (3-(2,2-diclorovinil)-2,2-dimetilciclopropanocarboxilato de a-ciano-3-fenoxi-4-fluorobencilo) es un insecticidad piretroide tipo ii o a-ciano usado ampliamente para el control de diversas plagas que causan da\u00f1os de gran importancia econ\u00f3mica. Existen estudios que demuestran que los piretroides se absorben a trav\u00e9s del tracto gastrointestinal, v\u00eda pulmonar y cut\u00e1nea, y que son metabolizados in vivo por esterasas y monooxigenasas. los piretroides tipo i y tipo ii sonagentes neurt\u00f3xicos para insectos y para mam\u00edferos y adem\u00e1s interaccionan con enzimas metabolziantes de xenobi\u00f3tico. hasta el momento no se ha descrito el comportamiento de la ciflutrina como inductor o inhibidor de la superfamilia de enzimas del citocromo p450.  el objetivo de nuestro trabajo fue evaluar, en ratas macho wistar de seis semanas de edad, el efecto de la adminsitraci\u00f3n prolongada de ciflutrina sobre diversas isoenzimas del citrocromo p450 microsomales hep\u00e1ticas y renales, as\u00ed como sobre enximas peroxisomales y de fase ii.  los resultados obtenidos en nurstro estudio demuestran que la ciflutrina se comprota como uninductor enzim\u00e1tico del sistema microsomal oxidasa de funci\u00f3n mixta, en particular de la sisoenzimas citocromo p4501a1\/2, p4502e y p4504a1. La ciflutrina, adem\u00e1s , induce la enzima peroxisomal palmitoil-coa oxidasa y la enzima mitocondrial carnitina acetilfransferasa, implicada tambi\u00e9n en la proliferaci\u00f3n de peroxisomas.  la ciflutrina, tras tratamiento prolongado, tambi\u00e9n origina una alteraci\u00f3n de la cin\u00e9tica de la antipirina (compuesto modelo para el estudio del metabolismo oxidativo), disminuyendo la semivida plasm\u00e1tica de eliminaci\u00f3n e incrementando el aclaramiento plasm\u00e1tico. Por otra parte, la ciflutrina induce la excreaci\u00f3nurinaria de los metabolitos de la antipirina: 3-hidroximetilantipriirna, 4-hidroxiantipirina y norantipirina.  los resultados descritos sugieren que la ciflutrina es un inductor enzim\u00e1ti<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Induccion de enzimas microsomales hepaticas y proliferacion peroxisomal por ciflutrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Induccion de enzimas microsomales hepaticas y proliferacion peroxisomal por ciflutrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Fern\u00e1ndez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Ramon Anadon Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li>elisa Marhuenda requena (vocal)<\/li>\n<li>Francisco Polledo jos\u00e9 (vocal)<\/li>\n<li>Mar\u00eda anunciaci\u00f3n Lafuente gim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Fern\u00e1ndez S\u00e1nchez La ciflutrina (3-(2,2-diclorovinil)-2,2-dimetilciclopropanocarboxilato de a-ciano-3-fenoxi-4-fluorobencilo) es un insecticidad piretroide tipo ii o a-ciano usado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,2444,401],"tags":[4663,7412,11334,178371,37292,178370],"class_list":["post-84430","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-naturales","category-toxicologia","tag-angel-villar-del-fresno","tag-arturo-ramon-anadon-navarro","tag-elisa-marhuenda-requena","tag-francisco-polledo-jose","tag-maria-anunciacion-lafuente-gimenez","tag-raquel-fernandez-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84430"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84430\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}