{"id":84439,"date":"2000-09-05T00:00:00","date_gmt":"2000-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hormona-tiroidea-sobre-la-expresion-de-genes-implicados-en-mecanismos-de-regulacion-post-transcripcional-en-cerebro\/"},"modified":"2000-09-05T00:00:00","modified_gmt":"2000-09-05T00:00:00","slug":"efecto-de-la-hormona-tiroidea-sobre-la-expresion-de-genes-implicados-en-mecanismos-de-regulacion-post-transcripcional-en-cerebro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-de-la-hormona-tiroidea-sobre-la-expresion-de-genes-implicados-en-mecanismos-de-regulacion-post-transcripcional-en-cerebro\/","title":{"rendered":"Efecto de la hormona tiroidea sobre la expresion de genes implicados en mecanismos de regulacion post-transcripcional en cerebro."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cuadrado Garcia M. Ana <\/strong><\/h2>\n<p>La hormona tiroidea (t3) desempe\u00f1a un papel esencial en el correcto desarrollo del snc de mam\u00edferos. La disminuci\u00f3n de los niveles normales de esta hormona en el hombre durante per\u00eddos cr\u00edticos del desarrollo provoca graves anomal\u00edas neurol\u00f3gicas y retraso mental severo. Con el objeto de comprender mejor los efectos de la hormona tiroidea sobre el desarrollo cerebral hemos buscado genes regulados por t3 en este \u00f3rgano. Para ello hemos utilizado la t\u00e9cnica de pcr diferencial con la l\u00ednea celular neurona e18 + tr sensible a t3. de este modo, hemos identificado el hom\u00f3logo en rata del gen swap de drosophila como un gen regulado por hormona tiroidea en esta l\u00ednea celular y durante el desarrollo del cerebro de rata. Hemos visto que el hipotiroidismo provoca un incremento de la expresi\u00f3n del rnam de swap entre los d\u00edas p5 y p15 en todas las regiones cerebrales a excepci\u00f3n del cerebelo.  numerosos estudios demuestran la existencia de m\u00faltiples genes regulados por hormona tir\u00f3idea en los que no se han identificado elementos de respuesta. esto sugiere que t3 puede estar implicada en mecanismos de regulaci\u00f3n post-transcripcional. en base a ello hemos estudiado el efecto del estado tiroideo sobre la expresi\u00f3n de msi-1 y hud, dos genes que codifican prote\u00ednas relacionadas con este tipo de procesos. Hemos observado que t3 incrementa los niveles de rnam y prote\u00edna msi-1 in vitro durante el per\u00edodo postnatal temprano. In vitro, el tratamiento con hormona tiroidea de c\u00e9lulas n2a que expresan niveles adecuados de receptores provoca un aumento de expresi\u00f3n de msi-1. Este efecto es espec\u00edfico de t3, y se debe probablemente a un efecto directo sobre la transcripci\u00f3n de este gen. Hemos demostrado que la expresi\u00f3n ex\u00f3gena de la prote\u00edna msi-1 en c\u00e9lulas n2a es responsable de un incremento en la proporci\u00f3n de isoformas maduras de tau que contiene el ex\u00f3n 10 respecto a las que no le contienen (isoformas inmaduras), siendo \u00e9ste el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hormona tiroidea sobre la expresion de genes implicados en mecanismos de regulacion post-transcripcional en cerebro.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hormona tiroidea sobre la expresion de genes implicados en mecanismos de regulacion post-transcripcional en cerebro. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cuadrado Garcia M. Ana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Mu\u00f1oz Terol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>Carlos Lopez otin (vocal)<\/li>\n<li>cecilio Gimenez martin (vocal)<\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cuadrado Garcia M. Ana La hormona tiroidea (t3) desempe\u00f1a un papel esencial en el correcto desarrollo del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[15488,5834,6730,178388,6285,4892],"class_list":["post-84439","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alberto-munoz-terol","tag-carlos-lopez-otin","tag-cecilio-gimenez-martin","tag-cuadrado-garcia-m-ana","tag-federico-mayor-menendez","tag-luis-miguel-garcia-segura"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=84439"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/84439\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=84439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=84439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=84439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}