{"id":84445,"date":"2000-10-05T00:00:00","date_gmt":"2000-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximacion-racionales-y-combinatorias-a-la-mimetizacion-de-un-sitio-antigencio-discontinuo\/"},"modified":"2000-10-05T00:00:00","modified_gmt":"2000-10-05T00:00:00","slug":"aproximacion-racionales-y-combinatorias-a-la-mimetizacion-de-un-sitio-antigencio-discontinuo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aproximacion-racionales-y-combinatorias-a-la-mimetizacion-de-un-sitio-antigencio-discontinuo\/","title":{"rendered":"Aproximaci\u00f3n racionales y combinatorias a la mimetizaci\u00f3n de un sitio antig\u00e9ncio discontinuo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Borr\u00e1s Ram\u00edrez <\/strong><\/h2>\n<p>En esta tesis se ha abordado la reconstrucci\u00f3n de un sitio antig\u00e9nico discontinuo, problema que se enmarca dentro de la qu\u00edmica del reconocimiento molecular. En concreto, se ha llevado a cabo la mimetizaci\u00f3n funcional del sitio antig\u00e9nico d del virus de la fiebre aftosa vfa a partir de la informaci\u00f3n inmunoqu\u00edmica y estructural que lo definen. Dicha mimetizaci\u00f3n se ha planteado desde dos aproximaciones conceptuales diferentes. Mediante el dise\u00f1o racional de construcciones pept\u00eddicas basadas en c\u00e1lculos de din\u00e1mica molecular se han obtenido estructuras inmunog\u00e9ncias. Es decir, dichas estructuras, en animales de laboratorio, han inducido una respuesta inmune que se dirige al vfa y espec\u00edficamente al sitio antig\u00e9nico d. Adem\u00e1s los sueros anto-p\u00e9ptido son capaces de neutralizar la infectividad del virus. Por otro lado, a partir de una aproximaci\u00f3n combinatoria, y m\u00e1s concretamente de la utilizaci\u00f3n de librer\u00edas pept\u00eddicas se han hallado estructuras antig\u00e9nicas, esto es, capaces de interaccionar con los anticuerpos monoclonales antisitio d. As\u00ed pues, siguiendo dos aproximaciones distintas se ha consegudio emular hasta cierto grado tanto la actividad inmunog\u00e9nica como la antig\u00e9nica del sitio antig\u00e9nico d de vfa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aproximaci\u00f3n racionales y combinatorias a la mimetizaci\u00f3n de un sitio antig\u00e9ncio discontinuo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aproximaci\u00f3n racionales y combinatorias a la mimetizaci\u00f3n de un sitio antig\u00e9ncio discontinuo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Borr\u00e1s Ram\u00edrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Andreu Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Albericio palomera <\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<li>Juan  ram\u00f3n Granja guill\u00e1n (vocal)<\/li>\n<li>ignacio Fita rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Borr\u00e1s Ram\u00edrez En esta tesis se ha abordado la reconstrucci\u00f3n de un sitio antig\u00e9nico discontinuo, problema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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