{"id":84481,"date":"2000-12-05T00:00:00","date_gmt":"2000-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-tratamiento-con-epomediol-sobre-las-alteraciones-hepatobiliares-inducidas-por-el-etinilestradiol-papel-de-los-acidos-biliares-y-del-glutation\/"},"modified":"2000-12-05T00:00:00","modified_gmt":"2000-12-05T00:00:00","slug":"efecto-del-tratamiento-con-epomediol-sobre-las-alteraciones-hepatobiliares-inducidas-por-el-etinilestradiol-papel-de-los-acidos-biliares-y-del-glutation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-del-tratamiento-con-epomediol-sobre-las-alteraciones-hepatobiliares-inducidas-por-el-etinilestradiol-papel-de-los-acidos-biliares-y-del-glutation\/","title":{"rendered":"Efecto del tratamiento con epomediol sobre las alteraciones hepatobiliares inducidas por el etinilestradiol: papel de los acidos biliares y del glutation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Jos\u00e9 Cuevas Gonz\u00e1lez <\/strong><\/h2>\n<p>El epomediol es un terpeno sintetico que revierte la colestasis inducida por el etinilestradiol. En un estudio previo demostramos el efecto coler\u00e9tico del epomediol, tanto en controles, como en animales con colestasis provocada por el tratamiento con el estrogeno sintetico etinilestradiol.  se hicieron cuatro grupos experimentales: animales control(grupo c), ratas con un tratamiento de 5 dias de epomediol (100 mg\/kg) (grupo e), ratas tratadas con etinilestradiol (5 mg\/kg) (grupo s)o bien una combinacion de etinilestradiol m\u00e1s epomediol(5 mg\/kg y 100 mg\/kg) (grupo se).  con objeto de profundizar en el mecanismo coleretico del epomediol se analizaron las actividades enzim\u00e1ticas claves en la sintesis de los acidos biliares y del colesterol: colesterol 7a-hidroxilasa y 3-hidroxi-3-metilglutaril-coenzima a reductasa (hmg-coa reductasa), respectivamente.  el epomediol indujo un incremento significativo en la actividad micros\u00f3mica colesterol 7a-hidroxilasa. En el grupo s existi\u00f3 una reducci\u00f3n de esta actividad enzim\u00e1tica, que se revirti\u00f3 totalmente con la administraci\u00f3n del terpeno. A su vez, la actividad hmg-coa reductasa se increment\u00f3 en todos los grupos experimentales.  el epomediol estimul\u00f3 la expresi\u00f3n de la actividad 7 a-hidroxilasa a nivel transcripcional en el grupo e; pero no en los grupos s y se. Esto parece indicar que, posiblemente, el terpeno utiliza otras vias de control adicionales que le permiten antagonizar la alteraci\u00f3n provocada por el estrogeno.  los niveles basales de expresi\u00f3n del arnm de la hmg-coa reductasa no se modificaron significativamente, asumiendose que, en esta actividad, se produce una modulaci\u00f3n principalmente post-transcripcional o una regulacion debida a la influencia de diversos factores.  las alteraciones en ambas actividades enzim\u00e1ticas tampoco fueron debidas a modificaciones en el entorno lipidico de la membrana micros\u00f3mica, pues no se detectaron variaciones ni en la fluidez ni en la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del tratamiento con epomediol sobre las alteraciones hepatobiliares inducidas por el etinilestradiol: papel de los acidos biliares y del glutation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del tratamiento con epomediol sobre las alteraciones hepatobiliares inducidas por el etinilestradiol: papel de los acidos biliares y del glutation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Jos\u00e9 Cuevas Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Gonz\u00e1lez Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esperanza Torija isaza <\/li>\n<li>Rafael Jimenez fern\u00e1ndez (vocal)<\/li>\n<li>Juan  Antonio Madrid perez (vocal)<\/li>\n<li>M\u00aa francisca Gonz\u00e1lez sevilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jos\u00e9 Cuevas Gonz\u00e1lez El epomediol es un terpeno sintetico que revierte la colestasis inducida por el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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