{"id":8449,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-la-toxicidad-de-la-heroina-por-via-intra-arterial\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-la-toxicidad-de-la-heroina-por-via-intra-arterial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-toxicidad-de-la-heroina-por-via-intra-arterial\/","title":{"rendered":"Estudio de la toxicidad de la heroina por via intra-arterial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Cervera Bravo <\/strong><\/h2>\n<p>La heroina es una de las drogas que se han relacionado con endarteritis quimica por casos clinicos aparecidos en la literatura, aunque sus mecanismos patogenicos no se han estudiado experimentalmente.Para determinar la toxicidad de la heroina por via intraarterial, se han comparado los efectos de la de procedencia farmacologica y la sintetizada a partir de productos naturales y destinada al consumo ilegal. El estudio se ha realizado mediante la inyeccion del producto en la arteria femoral izquierda de veintiseis mini cerdos. En todos los casos se ha inyectado suero salino en la arteria femoral derecha como control. El seguimiento hasta el sacrificio del animal ha sido de 72 horas.  con la heroina decomisada se ha producido una reaccion inmediata generalmente reversible, consistente en un eritema de intensidad variable, que ha afectado fundamentalmente a genitales y region glutea, asi como una necrosis muscular parcheada acompa\u00f1ada en raras ocasiones de necrosis cutanea. Esta reaccion ha presentado una repercusion enzimatica y metabolica, valorada mediante el analisis de muestras de sangre obtenidas diariamente. La reaccion se ha mantenido en con heroina esterilizada, por lo que su toxicidad se puede atribuir a sus impurezas quimicas.  cabe destacar como rasgo principal de la lesion producida, la evolucion rapida, con respuesta inmediata masiva, y la escasa necrosis tisular.  la heroina sin impurezas no ha causado lesion significativa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la toxicidad de la heroina por via intra-arterial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la toxicidad de la heroina por via intra-arterial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Cervera Bravo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Manuel San Roman Teran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez Montes <\/li>\n<li> Paredero Del Bosque Martin Vicente (vocal)<\/li>\n<li>JavierFrancisco Regadera Gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Luis Vallejo Ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Cervera Bravo La heroina es una de las drogas que se han relacionado con endarteritis quimica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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